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We have examined the interaction between phosphoribosyltransferase and purified tRNA-His from the wild type strain of Salmonella typhimurium, LT-2, and the histidine regulatory mutant hisTl504. Histidyl-tRNA from the mutant strain functions normally in protein synthesis but is defective in its role in the repression mechanism of the histidine operon. Phosphoribosyltransferase has been suggested as a possible aporegulator for this operon and as such might be expected to interact abnormally with tRNA-His from hisT1504. In these studies we have been unable to detect any difference between the affinities of phosphoribosyltransferase for tRNA-His from LT-2 or hisT1504, and thus we conclude that if the complex between phosphoribosyltransferase and histidyl-tRNA does function in regulation, the defect in the hisT1504 mutant must influence the interaction of the complex with some other regulatory element.
R G Deeley, and
R F Goldberger, and
J S Kovach, and
M M Meyers, and
K P Mullinix
December 1972,
FEBS letters,
R G Deeley, and
R F Goldberger, and
J S Kovach, and
M M Meyers, and
K P Mullinix
October 1971,
Journal of bacteriology,
R G Deeley, and
R F Goldberger, and
J S Kovach, and
M M Meyers, and
K P Mullinix
October 1969,
Journal of molecular biology,
R G Deeley, and
R F Goldberger, and
J S Kovach, and
M M Meyers, and
K P Mullinix
February 1975,
Journal of bacteriology,
R G Deeley, and
R F Goldberger, and
J S Kovach, and
M M Meyers, and
K P Mullinix
February 1971,
The Journal of biological chemistry,
R G Deeley, and
R F Goldberger, and
J S Kovach, and
M M Meyers, and
K P Mullinix
February 1972,
Journal of bacteriology,
R G Deeley, and
R F Goldberger, and
J S Kovach, and
M M Meyers, and
K P Mullinix
February 1977,
Journal of bacteriology,
R G Deeley, and
R F Goldberger, and
J S Kovach, and
M M Meyers, and
K P Mullinix
June 1977,
Nucleic acids research,
R G Deeley, and
R F Goldberger, and
J S Kovach, and
M M Meyers, and
K P Mullinix
August 1975,
European journal of biochemistry,
R G Deeley, and
R F Goldberger, and
J S Kovach, and
M M Meyers, and
K P Mullinix
November 1990,
Biochemistry,
