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Genotoxicity evaluation of heat shock was carried out in Carassius auratus. The genotoxicity end points studied were nuclear anomalies (micronucleus assay), chromosomal aberrations, DNA damage (comet assay) and cell proliferation. The heat shock temperatures used were 34 degrees C, 36 degrees C and 38 degrees C. The results demonstrated that heat shock causes the induction of micronucleus at all the three temperature studied. Heat shock also inhibited cell proliferation at 38 degrees C and caused aberrations in the metaphase chromosomes at 34 degrees C and 36 degrees C. Comet assay demonstrated single strand DNA damage at all the three temperatures. The results obtained indicate that heat shock is a genotoxicant.
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