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In mammals, neuropeptide Y (NPY) is a potent orexigenic factor. In the present study, third brain ventricle (intracerebroventricular) injection of goldfish NPY (gNPY) caused a dose-dependent increase in food intake in goldfish, and intracerebroventricular administration of NPY Y1-receptor antagonist BIBP-3226 decreased food intake; the actions of gNPY were blocked by simultaneous injection of BIBP-3226. Goldfish maintained on a daily scheduled feeding regimen display an increase in NPY mRNA levels in the telencephalon-preoptic area and hypothalamus shortly before feeding; however, a decrease occured in optic tectum-thalamus. In both fed and unfed fish, brain NPY mRNA levels decreased after scheduled feeding. Restriction in daily food ration intake for 1 wk or food deprivation for 72 h resulted in increased brain NPY mRNA levels. Results from these studies demonstrate that NPY is a physiological brain signal involved in feeding behavior in goldfish, mediating its effects, at least in part, through Y1-like receptors in the brain.
Y K Narnaware, and
P P Peyon, and
X Lin, and
R E Peter
January 2022,
Current medicinal chemistry,
Y K Narnaware, and
P P Peyon, and
X Lin, and
R E Peter
August 1993,
Annals of the New York Academy of Sciences,
Y K Narnaware, and
P P Peyon, and
X Lin, and
R E Peter
September 1987,
The American journal of physiology,
Y K Narnaware, and
P P Peyon, and
X Lin, and
R E Peter
February 2002,
Regulatory peptides,
Y K Narnaware, and
P P Peyon, and
X Lin, and
R E Peter
February 2005,
Nutrition (Burbank, Los Angeles County, Calif.),
Y K Narnaware, and
P P Peyon, and
X Lin, and
R E Peter
November 1961,
The American journal of physiology,
Y K Narnaware, and
P P Peyon, and
X Lin, and
R E Peter
January 2001,
Physiology & behavior,
Y K Narnaware, and
P P Peyon, and
X Lin, and
R E Peter
November 2009,
Peptides,
Y K Narnaware, and
P P Peyon, and
X Lin, and
R E Peter
July 2003,
Nutrition reviews,
Y K Narnaware, and
P P Peyon, and
X Lin, and
R E Peter
April 2022,
Veterinary sciences,
