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Development of CD4+ helper T (Th) cells into type 1 (Th1) or type 2 (Th2) effectors, as characterized by their opposite pattern of cytokine production, can be influenced by several factors, including hormones. Progesterone promotes the production of IL-4 and IL-5, whereas relaxin promotes the production of IFN-gamma by T cells. Leukemia inhibitory factor (LIF), essential for embryo implantation, is up-regulated by IL-4 and progesterone. Moreover, the production of LIF and/or Th2 cytokines by decidual T cells contributes to the maintenance of pregnancy. Our results suggest that relaxin and progesterone may contribute to the regulation of the immune homeostasis during pregnancy.
M P Piccinni, and
C Scaletti, and
E Maggi, and
S Romagnani
January 1996,
Immunologic research,
M P Piccinni, and
C Scaletti, and
E Maggi, and
S Romagnani
June 2004,
International archives of allergy and immunology,
M P Piccinni, and
C Scaletti, and
E Maggi, and
S Romagnani
August 1994,
Immunological reviews,
M P Piccinni, and
C Scaletti, and
E Maggi, and
S Romagnani
January 1996,
Biological signals,
M P Piccinni, and
C Scaletti, and
E Maggi, and
S Romagnani
October 2006,
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie,
M P Piccinni, and
C Scaletti, and
E Maggi, and
S Romagnani
July 1998,
Immunology today,
M P Piccinni, and
C Scaletti, and
E Maggi, and
S Romagnani
January 2003,
Current pharmaceutical design,
M P Piccinni, and
C Scaletti, and
E Maggi, and
S Romagnani
August 2005,
Acta obstetricia et gynecologica Scandinavica,
M P Piccinni, and
C Scaletti, and
E Maggi, and
S Romagnani
January 1996,
Chemical immunology,
M P Piccinni, and
C Scaletti, and
E Maggi, and
S Romagnani
December 2008,
Transplantation proceedings,
