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The naturally occurring stilbene/alexin trans-resveratrol (trans-3,5, 4'-trihydroxystilbene) is a promising agent for the prevention of cancer. We investigated the effect of resveratrol on gap-junctional intercellular communication (GJIC) in WB-F344 rat liver epithelial cells because inhibition of GJIC is an important mechanism of tumor promotion. Seventeen to 50 microM resveratrol increased GJIC significantly by a factor of 1.3 compared with solvent vehicle controls, when the WB-F344 cells were exposed to resveratrol for 6 h. Most tumor promoters, including the phorbol ester TPA and the insecticide DDT, block GJIC. Resveratrol at 17-50 microM also significantly prevented down-regulation of GJIC by TPA and DDT, by a factor of 2.7 and 1.8, respectively. This recovery of GJIC from TPA inhibition was partly correlated with hindered hyperphosphorylation of Cx43. In conclusion, resveratrol was found to enhance GJIC and counteract the effects of tumor promoters on GJIC, and this is likely a mechanism that contributes to the antipromotional and anticarcinogenic properties of resveratrol.
M Nielsen, and
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O Vang
February 1997,
Environmental toxicology and pharmacology,
M Nielsen, and
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July 2006,
Nan fang yi ke da xue xue bao = Journal of Southern Medical University,
M Nielsen, and
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M Nielsen, and
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M Nielsen, and
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M Nielsen, and
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September 2016,
Toxicology and applied pharmacology,
M Nielsen, and
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O Vang
April 1994,
Sheng li ke xue jin zhan [Progress in physiology],
M Nielsen, and
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April 1993,
Cancer letters,
