Biomaterial Database

Sec1/Munc18 proteins: mediators of membrane fusion moving to center stage. 2000

R Jahn

Department of Neurobiology, Max Planck Institute for Biophysical Chemistry, Göttingen, Federal Republic of Germany. rjahn@gwdg.de

UI	MeSH Term	Description	Entries
D008561	Membrane Fusion	The adherence and merging of cell membranes, intracellular membranes, or artificial membranes to each other or to viruses, parasites, or interstitial particles through a variety of chemical and physical processes.	Fusion, Membrane,Fusions, Membrane,Membrane Fusions
D008565	Membrane Proteins	Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors.	Cell Membrane Protein,Cell Membrane Proteins,Cell Surface Protein,Cell Surface Proteins,Integral Membrane Proteins,Membrane-Associated Protein,Surface Protein,Surface Proteins,Integral Membrane Protein,Membrane Protein,Membrane-Associated Proteins,Membrane Associated Protein,Membrane Associated Proteins,Membrane Protein, Cell,Membrane Protein, Integral,Membrane Proteins, Integral,Protein, Cell Membrane,Protein, Cell Surface,Protein, Integral Membrane,Protein, Membrane,Protein, Membrane-Associated,Protein, Surface,Proteins, Cell Membrane,Proteins, Cell Surface,Proteins, Integral Membrane,Proteins, Membrane,Proteins, Membrane-Associated,Proteins, Surface,Surface Protein, Cell
D008958	Models, Molecular	Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.	Molecular Models,Model, Molecular,Molecular Model
D009419	Nerve Tissue Proteins		Proteins, Nerve Tissue,Tissue Proteins, Nerve
D009435	Synaptic Transmission	The communication from a NEURON to a target (neuron, muscle, or secretory cell) across a SYNAPSE. In chemical synaptic transmission, the presynaptic neuron releases a NEUROTRANSMITTER that diffuses across the synaptic cleft and binds to specific synaptic receptors, activating them. The activated receptors modulate specific ion channels and/or second-messenger systems in the postsynaptic cell. In electrical synaptic transmission, electrical signals are communicated as an ionic current flow across ELECTRICAL SYNAPSES.	Neural Transmission,Neurotransmission,Transmission, Neural,Transmission, Synaptic
D011487	Protein Conformation	The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain).	Conformation, Protein,Conformations, Protein,Protein Conformations
D050600	SNARE Proteins	A superfamily of small proteins which are involved in the MEMBRANE FUSION events, intracellular protein trafficking and secretory processes. They share a homologous SNARE motif. The SNARE proteins are divided into subfamilies: QA-SNARES; QB-SNARES; QC-SNARES; and R-SNARES. The formation of a SNARE complex (composed of one each of the four different types SNARE domains (Qa, Qb, Qc, and R)) mediates MEMBRANE FUSION. Following membrane fusion SNARE complexes are dissociated by the NSFs (N-ETHYLMALEIMIDE-SENSITIVE FACTORS), in conjunction with SOLUBLE NSF ATTACHMENT PROTEIN, i.e., SNAPs (no relation to SNAP 25.)	SNAP Receptor,SNARE Protein,NSF Attachment Protein Receptor,Receptor, SNAP,SNAP Receptors,SNARE,SNAREs,Soluble N-ethylmaleimide-Sensitive-Factor Attachment Protein Receptor,Target Membrane SNARE Proteins,Target SNARE Proteins,Vesicle SNARE Proteins,Vesicular SNARE Proteins,t-SNARE,tSNAREs,v-SNARE,v-SNAREs,Protein, SNARE,SNARE Proteins, Target,SNARE Proteins, Vesicle,SNARE Proteins, Vesicular,Soluble N ethylmaleimide Sensitive Factor Attachment Protein Receptor,v SNAREs
D050765	Qa-SNARE Proteins	A subfamily of Q-SNARE PROTEINS which occupy the same position as syntaxin 1A in the SNARE complex and which also are most similar to syntaxin 1A in their AMINO ACID SEQUENCE. This subfamily is also known as the syntaxins, although a few so called syntaxins are Qc-SNARES.	Qa-SNAREs,Syntaxin,Syntaxin 10,Syntaxin 10 Protein,Syntaxin 11,Syntaxin 11 Protein,Syntaxin 13,Syntaxin 13 Protein,Syntaxin 17,Syntaxin 17 Protein,Syntaxin 18,Syntaxin 18 Protein,Syntaxin 1A Homologs,Syntaxin 3,Syntaxin 3 Protein,Syntaxin 3A,Syntaxin 3A Protein,Syntaxin 3B,Syntaxin 3B Protein,Syntaxin 3C,Syntaxin 3C Protein,Syntaxin 3D,Syntaxin 3D Protein,Syntaxin 4,Syntaxin 4 Protein,Syntaxin 5,Syntaxin 5 Protein,Syntaxin 6,Syntaxin 6 Protein,Syntaxin 7,Syntaxin 7 Protein,Syntaxin 8,Syntaxin 8 Protein,Syntaxin Protein,Syntaxin Proteins,Syntaxins,Protein, Syntaxin,Protein, Syntaxin 11,Proteins, Syntaxin,Qa SNARE Proteins,Qa SNAREs
D051938	Munc18 Proteins	A family of proteins involved in intracellular membrane trafficking. They interact with SYNTAXINS and play important roles in vesicular docking and fusion during EXOCYTOSIS. Their name derives from the fact that they are related to Unc-18 protein, C elegans.	Munc-18 Proteins,Munc-18b Protein,Munc18 Syntaxin Binding Proteins,Munc18-1 Protein,Munc18-2 Protein,Munc18-3 Protein,Munc18a Protein,Munc18b Protein,Munc18c Protein,Sec1-Munc18 Protein Family,Syntaxin Binding Protein Munc18,Munc 18 Proteins,Sec1 Munc18 Protein Family
D020691	rab GTP-Binding Proteins	A large family of MONOMERIC GTP-BINDING PROTEINS that play a key role in cellular secretory and endocytic pathways.	Rab GTPase,rab G-Proteins,rab GTP-Binding Protein,rab GTPases,G-Proteins, rab,GTP-Binding Protein, rab,GTP-Binding Proteins, rab,GTPase, Rab,GTPases, rab,Protein, rab GTP-Binding,rab G Proteins,rab GTP Binding Protein,rab GTP Binding Proteins