Biomaterial Database

Gastric acid secretion following renal transplantation. 1975

J S Canavan, and J D Briggs, and P R Bell

Gastric acid secretion studies were performed in 10 patients on regular dialysis and again following transplantation. While on dialysis, the acid output was high, with mean peak values after pentagastrin of 37-2 mEq/h in males and 26-3 mEq/h in females. These compared with values in normal subjects of 21-6 mEq/h in males and 12-3 mEq/h in females. Following transplantation continuous steroid therapy was given. Repear gastric acid secretion studies showed no significant change, with values of 37-1 mEq/h in males and 24-6 mEq/h in females. The high incidence of gastro-intestinal haemorrhage and perforation following transplantation is probably due mainly to steroid therapy, but the ulcerogenic effect of steroids would not seem to be mediated by increased gastric acid secretion.

UI	MeSH Term	Description	Entries
D007416	Intestinal Perforation	Opening or penetration through the wall of the INTESTINES.	Intestinal Perforations,Perforation, Intestinal,Perforations, Intestinal
D008297	Male		Males
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D010418	Pentagastrin	A synthetic pentapeptide that has effects like gastrin when given parenterally. It stimulates the secretion of gastric acid, pepsin, and intrinsic factor, and has been used as a diagnostic aid.	Acignost,Gastrin Pentapeptide,Peptavlon,Pentapeptide, Gastrin
D010438	Peptic Ulcer Hemorrhage	Bleeding from a PEPTIC ULCER that can be located in any segment of the GASTROINTESTINAL TRACT.	Hemorrhage, Peptic Ulcer,Peptic Ulcer Hemorrhages,Ulcer Hemorrhage, Peptic
D011183	Postoperative Complications	Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.	Complication, Postoperative,Complications, Postoperative,Postoperative Complication
D011239	Prednisolone	A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states.	Di-Adreson-F,Predate,Predonine,Di Adreson F,DiAdresonF
D004381	Duodenal Ulcer	A PEPTIC ULCER located in the DUODENUM.	Curling's Ulcer,Curling Ulcer,Curlings Ulcer,Duodenal Ulcers,Ulcer, Curling,Ulcer, Duodenal,Ulcers, Duodenal
D004415	Dyspepsia	Impaired digestion, especially after eating.	Indigestion,Dyspepsias,Indigestions
D005260	Female		Females