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Ticlopidine is a new platelet aggregation inhibitor. The effect of this drug was studied on 55 subjects, healthy volunteers and hospitalized patients. The action requires 24 to 48 hr to appear, and lasts more than 3 days. A dose-effect relationship was studied with oral daily doses ranging from 250 to 1,000 mg during 1 wk; it showed a 50% inhibition on adenosine diphosphate (ADP)-induced aggregation at 2 muM concentration on an oral daily dose of 450 mg. No action was found on collagen-induced aggregation, and a mild effect was observed on platelet adhesiveness. Clinical tolerance was assessed in patients given ticlopidine in oral doses up to 500 mg/day during several weeks, showing no overt side effects and no change in the safety parameters.
J J Thebault, and
C E Blatrix, and
J F Blanchard, and
E A Panak
July 1992,
Clinical pharmacy,
J J Thebault, and
C E Blatrix, and
J F Blanchard, and
E A Panak
January 1979,
Archivio "E. Maragliano" di patologia e clinica,
J J Thebault, and
C E Blatrix, and
J F Blanchard, and
E A Panak
June 1978,
Thrombosis research,
J J Thebault, and
C E Blatrix, and
J F Blanchard, and
E A Panak
January 1980,
Arzneimittel-Forschung,
J J Thebault, and
C E Blatrix, and
J F Blanchard, and
E A Panak
February 1979,
Thrombosis and haemostasis,
J J Thebault, and
C E Blatrix, and
J F Blanchard, and
E A Panak
January 1980,
Arzneimittel-Forschung,
J J Thebault, and
C E Blatrix, and
J F Blanchard, and
E A Panak
May 1993,
Transplantation,
J J Thebault, and
C E Blatrix, and
J F Blanchard, and
E A Panak
March 1984,
Clinical nephrology,
J J Thebault, and
C E Blatrix, and
J F Blanchard, and
E A Panak
October 1985,
Neurologia medico-chirurgica,
J J Thebault, and
C E Blatrix, and
J F Blanchard, and
E A Panak
December 1988,
The Journal of antibiotics,
