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The effects of intracarotid injection of synthetic luteinizing hormone releasing factor (LRF) on the ultrastructure of pituitary gonadotrophs are reported. Chronically ovariectomized rats of the Sprague-Dawley strain pretreated with oestradiol and progesterone were sacrificed at zero time and at 30, 120 min after injection of 1 mug of synthetic LRF. A careful observation was made for evidence of granule extrusion from gonadotrophs following intracarotid injection of LRF, but no signs of granule extrusion were demonstrated. However, granule migration to the periphery of the cell was observed 30 min after LRF injection and the distribution of secretory granules recovered 2 hours after injection. The result of ultrastructural observations suggests that LRF plays an important role in releasing and synthesizing gonadotrophins in pituitary gonadotrophs. Further investigations should elucidate more clearly the morphologic aspect of mode of LRF action in pituitary gonadotrophs.
R Nakano, and
W Lee, and
K Hayashi, and
S Tojo
January 1973,
Acta obstetricia et gynecologica Scandinavica,
R Nakano, and
W Lee, and
K Hayashi, and
S Tojo
February 1973,
Biochemical and biophysical research communications,
R Nakano, and
W Lee, and
K Hayashi, and
S Tojo
September 1979,
Fertility and sterility,
R Nakano, and
W Lee, and
K Hayashi, and
S Tojo
October 1979,
Life sciences,
R Nakano, and
W Lee, and
K Hayashi, and
S Tojo
January 1977,
Advances in experimental medicine and biology,
R Nakano, and
W Lee, and
K Hayashi, and
S Tojo
May 1973,
The Journal of physiology,
R Nakano, and
W Lee, and
K Hayashi, and
S Tojo
March 1974,
Endokrinologie,
R Nakano, and
W Lee, and
K Hayashi, and
S Tojo
August 1973,
The Journal of clinical endocrinology and metabolism,
R Nakano, and
W Lee, and
K Hayashi, and
S Tojo
January 1975,
Neuroendocrinology,
R Nakano, and
W Lee, and
K Hayashi, and
S Tojo
May 1973,
Endocrinology,
