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The effect of pH on the red blood cell (RBC) deformability, which is a consequence of a change of cell membrane elastic properties is studied experimentally. With the intention to reduce the effects on deformability of cell geometry and cytoplasmic viscosity, we measured the deformability of the cells with the same volume at various pH of cell suspension from 6.2 to 8.0. Constant cell volume was achieved by varying osmolarity. Deformability was quantified by measuring the elongation of RBCs subjected to velocity gradient in a transparent cone-plate rheoscope. Observed significant decrease of deformability at lower pH leads to the conclusion that membrane elastic properties could be affected by pH changes in the range from 6.2 to 8.0.
D Kuzman, and
T Znidarcic, and
M Gros, and
S Vrhovec, and
S Svetina, and
B Zeks
January 2000,
Pflugers Archiv : European journal of physiology,
D Kuzman, and
T Znidarcic, and
M Gros, and
S Vrhovec, and
S Svetina, and
B Zeks
January 1985,
Blood cells,
D Kuzman, and
T Znidarcic, and
M Gros, and
S Vrhovec, and
S Svetina, and
B Zeks
January 2007,
Biorheology,
D Kuzman, and
T Znidarcic, and
M Gros, and
S Vrhovec, and
S Svetina, and
B Zeks
January 1985,
European journal of clinical pharmacology,
D Kuzman, and
T Znidarcic, and
M Gros, and
S Vrhovec, and
S Svetina, and
B Zeks
January 1999,
Frontiers of medical and biological engineering : the international journal of the Japan Society of Medical Electronics and Biological Engineering,
D Kuzman, and
T Znidarcic, and
M Gros, and
S Vrhovec, and
S Svetina, and
B Zeks
November 1992,
Journal of clinical pharmacology,
D Kuzman, and
T Znidarcic, and
M Gros, and
S Vrhovec, and
S Svetina, and
B Zeks
January 2005,
Hypertension in pregnancy,
D Kuzman, and
T Znidarcic, and
M Gros, and
S Vrhovec, and
S Svetina, and
B Zeks
April 1992,
Arzneimittel-Forschung,
D Kuzman, and
T Znidarcic, and
M Gros, and
S Vrhovec, and
S Svetina, and
B Zeks
January 1987,
International journal of microcirculation, clinical and experimental,
D Kuzman, and
T Znidarcic, and
M Gros, and
S Vrhovec, and
S Svetina, and
B Zeks
November 1984,
The American journal of physiology,
