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Two injectable betamethasone preparations, betamethasone dipropionate/betamethasone phosphate and betamethasone acetate/betamethasone phosphate were compared in a controlled trial on 22 "matched patient pairs" with rheumatic diseases. The two preparations were injected intra-articularly in knee joints affected by active synovitis. The time until onset of action and the duration of clinically adequate anti-inflammatory effect were recorded. All injections produced clinically significant effects. The interval before recurrence of symptoms varied from 2 days to more than 3 months. The dipropionate form showed statistically significantly longer duration of action. No difference was noted in the time until onset of action. Local side effects were not observed. The double-blind method of clinical evaluation proved useful in comparing duration of action between long-acting corticosteroids.
G Husby, and
E Kåss, and
K L Spongsveen
April 1971,
Journal de medecine de Lyon,
G Husby, and
E Kåss, and
K L Spongsveen
January 1962,
British medical journal,
G Husby, and
E Kåss, and
K L Spongsveen
May 1971,
Acta dermato-venereologica. Supplementum,
G Husby, and
E Kåss, and
K L Spongsveen
February 2021,
The bone & joint journal,
G Husby, and
E Kåss, and
K L Spongsveen
January 1987,
Scandinavian journal of rheumatology. Supplement,
G Husby, and
E Kåss, and
K L Spongsveen
August 1964,
Journal of the Irish Medical Association,
G Husby, and
E Kåss, and
K L Spongsveen
November 2025,
The Journal of bone and joint surgery. American volume,
G Husby, and
E Kåss, and
K L Spongsveen
January 2009,
Arthritis research & therapy,
G Husby, and
E Kåss, and
K L Spongsveen
January 1997,
Terapevticheskii arkhiv,
G Husby, and
E Kåss, and
K L Spongsveen
September 2015,
Revue medicale de Bruxelles,
