Biomaterial Database

Secondary hyperparathyroidism and phosphate sensing in parathyroid glands. 2000

K Miyamoto, and M Ito, and H Segawa, and M Kuwahata

Department of Nutritional Science, University of Tokushima School of Medicine, Japan.

Retention of inorganic phosphate (Pi) and associated hyperphosphatemia are important development of hyperparathyroidism secondary to renal failure. The beneficial effect of a low-Pi diet in the prevention of hyperparathyroidism can be attributed to the decrease in PTH secretion. This effect of Pi may be mediated by specific molecules in the parathyroid cell membrane. A complementary DNA encoding a Na(+)-Pi co-transporter, termed rat PiT-1, has been isolated from rat parathyroid. The amount of PiT-1 mRNA in the parathyroid is controlled by vitamin D and dietary Pi, which are the most important regulators of PTH secretion. The parathyroid Pi transporter may mediate the effects of extracellular Pi and PTH secretion in secondary hyperparathyroidism. In this study, we focus on the function of Na/Pi co-transporters in the parathyroid glands as inorganic Pi sensor.

UI	MeSH Term	Description	Entries
D006961	Hyperparathyroidism	A condition of abnormally elevated output of PARATHYROID HORMONE (or PTH) triggering responses that increase blood CALCIUM. It is characterized by HYPERCALCEMIA and BONE RESORPTION, eventually leading to bone diseases. PRIMARY HYPERPARATHYROIDISM is caused by parathyroid HYPERPLASIA or PARATHYROID NEOPLASMS. SECONDARY HYPERPARATHYROIDISM is increased PTH secretion in response to HYPOCALCEMIA, usually caused by chronic KIDNEY DISEASES.
D010280	Parathyroid Glands	Two pairs of small oval-shaped glands located in the front and the base of the NECK and adjacent to the two lobes of THYROID GLAND. They secrete PARATHYROID HORMONE that regulates the balance of CALCIUM; PHOSPHORUS; and MAGNESIUM in the body.	Gland, Parathyroid,Glands, Parathyroid,Parathyroid Gland
D010710	Phosphates	Inorganic salts of phosphoric acid.	Inorganic Phosphate,Phosphates, Inorganic,Inorganic Phosphates,Orthophosphate,Phosphate,Phosphate, Inorganic
D002352	Carrier Proteins	Proteins that bind or transport specific substances in the blood, within the cell, or across cell membranes.	Binding Proteins,Carrier Protein,Transport Protein,Transport Proteins,Binding Protein,Protein, Carrier,Proteins, Carrier
D003001	Cloning, Molecular	The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.	Molecular Cloning
D005786	Gene Expression Regulation	Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.	Gene Action Regulation,Regulation of Gene Expression,Expression Regulation, Gene,Regulation, Gene Action,Regulation, Gene Expression
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D014807	Vitamin D	A vitamin that includes both CHOLECALCIFEROLS and ERGOCALCIFEROLS, which have the common effect of preventing or curing RICKETS in animals. It can also be viewed as a hormone since it can be formed in SKIN by action of ULTRAVIOLET RAYS upon the precursors, 7-dehydrocholesterol and ERGOSTEROL, and acts on VITAMIN D RECEPTORS to regulate CALCIUM in opposition to PARATHYROID HORMONE.
D050608	Sodium-Phosphate Cotransporter Proteins	A family of symporters that facilitate sodium-dependent membrane transport of phosphate.	Sodium Phosphate Transporter,Sodium Phosphate Transporters,Sodium-Phosphate Cotransporter,Sodium-Phosphate Symporters,Cotransporter Proteins, Sodium-Phosphate,Phosphate Transporter, Sodium,Phosphate Transporters, Sodium,Sodium Phosphate Cotransporter,Sodium Phosphate Cotransporter Proteins,Sodium Phosphate Symporters,Symporters, Sodium-Phosphate,Transporters, Sodium Phosphate
D050611	Sodium-Phosphate Cotransporter Proteins, Type III	A family of highly conserved and widely expressed sodium-phosphate cotransporter proteins. They are electrogenic sodium-dependent transporters of phosphate that were originally identified as retroviral receptors in HUMANS and have been described in yeast and many other organisms.	Type III Sodium-Phosphate Cotransporter Proteins,Amphoteric Virus Receptor GLVR-2,Amphotropic MuLV Receptor,Amphotropic Murine Leukemia Virus Receptor,GLVR-2 Receptor,GLVR1 Transporter Proteins,NPT1 Protein,Pit1 Sodium-Dependent Phosphate Symporter,Pit1 Sodium-Phosphate Cotransporter,Pit2 Sodium-Dependent Phosphate Symporter,Pit2 Sodium-Phosphate Cotransporter,Ram-1 Receptor,SLC20A1 Transporter,Solute Carrier Family 20 (Phosphate Transporter), Member 1,Solute Carrier Family 20 (Phosphate Transporter), Member 2,Type III Na-Dependent Phosphate Cotransporter,Type III Sodium-Phosphate Symporter Proteins,Amphoteric Virus Receptor GLVR 2,Cotransporter, Pit1 Sodium-Phosphate,Cotransporter, Pit2 Sodium-Phosphate,GLVR 2 Receptor,MuLV Receptor, Amphotropic,Pit1 Sodium Dependent Phosphate Symporter,Pit1 Sodium Phosphate Cotransporter,Pit2 Sodium Dependent Phosphate Symporter,Pit2 Sodium Phosphate Cotransporter,Ram 1 Receptor,Receptor, Ram-1,Sodium Phosphate Cotransporter Proteins, Type III,Sodium-Phosphate Cotransporter, Pit1,Sodium-Phosphate Cotransporter, Pit2,Transporter Proteins, GLVR1,Type III Na Dependent Phosphate Cotransporter,Type III Sodium Phosphate Cotransporter Proteins,Type III Sodium Phosphate Symporter Proteins