BIOMAT Database Logo BIOMAT Database Logo

Prenatal exposure to low levels of carbon monoxide alters sciatic nerve myelination in rat offspring. 2000

M R Carratù, and R Cagiano, and S Desantis, and M Labate, and M Tattoli, and L Trabace, and V Cuomo
Department of Pharmacology and Human Physiology, Medical School, Faculty of Biological Sciences, University of Bari, Policlinico, Italy.

Prenatal exposure to low concentrations of carbon monoxide (CO, 75 and 150 ppm from day 0 to day 20 of gestation), resulting in maternal blood HbCO concentrations equivalent to those maintained by human cigarette smokers, leads to subtle myelin alterations in the sciatic nerve of male rat offspring. The rapid growth spurt in pup body weight was related to the period of maximal increase in myelin sheath thickness in both control and CO-exposed animals. A significant reduction in myelin sheath thickness of sciatic nerve fibers, paralleled by changes in the frequency distribution, occurred in both 40- and 90-day-old rats exposed in utero to CO (75 and 150 ppm). Myelin deficit observed in 75 and 150 ppm CO-exposed animals showed up only after the major spurt in myelination but not early during development. The subtle myelin alterations observed in CO-exposed offspring were not accompanied by changes in developmental pattern of axon diameters and did not result in a gross impairment of motor activity. These results suggest that the myelination process is selectively targeted by a prenatal exposure model simulating the CO exposure observed in human cigarette smokers.

UI MeSH Term Description Entries
D008297 Male Males
D009043 Motor Activity Body movements of a human or an animal as a behavioral phenomenon. Activities, Motor,Activity, Motor,Motor Activities
D009186 Myelin Sheath The lipid-rich sheath surrounding AXONS in both the CENTRAL NERVOUS SYSTEMS and PERIPHERAL NERVOUS SYSTEM. The myelin sheath is an electrical insulator and allows faster and more energetically efficient conduction of impulses. The sheath is formed by the cell membranes of glial cells (SCHWANN CELLS in the peripheral and OLIGODENDROGLIA in the central nervous system). Deterioration of the sheath in DEMYELINATING DISEASES is a serious clinical problem. Myelin,Myelin Sheaths,Sheath, Myelin,Sheaths, Myelin
D011247 Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH. Gestation,Pregnancies
D011297 Prenatal Exposure Delayed Effects The consequences of exposing the FETUS in utero to certain factors, such as NUTRITION PHYSIOLOGICAL PHENOMENA; PHYSIOLOGICAL STRESS; DRUGS; RADIATION; and other physical or chemical factors. These consequences are observed later in the offspring after BIRTH. Delayed Effects, Prenatal Exposure,Late Effects, Prenatal Exposure
D012044 Regression Analysis Procedures for finding the mathematical function which best describes the relationship between a dependent variable and one or more independent variables. In linear regression (see LINEAR MODELS) the relationship is constrained to be a straight line and LEAST-SQUARES ANALYSIS is used to determine the best fit. In logistic regression (see LOGISTIC MODELS) the dependent variable is qualitative rather than continuously variable and LIKELIHOOD FUNCTIONS are used to find the best relationship. In multiple regression, the dependent variable is considered to depend on more than a single independent variable. Regression Diagnostics,Statistical Regression,Analysis, Regression,Analyses, Regression,Diagnostics, Regression,Regression Analyses,Regression, Statistical,Regressions, Statistical,Statistical Regressions
D001835 Body Weight The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms. Body Weights,Weight, Body,Weights, Body
D002248 Carbon Monoxide Carbon monoxide (CO). A poisonous colorless, odorless, tasteless gas. It combines with hemoglobin to form carboxyhemoglobin, which has no oxygen carrying capacity. The resultant oxygen deprivation causes headache, dizziness, decreased pulse and respiratory rates, unconsciousness, and death. (From Merck Index, 11th ed) Monoxide, Carbon
D002263 Carboxyhemoglobin Carbomonoxyhemoglobin,Carbonmonoxyhemoglobin,Carbonylhemoglobin,Carboxyhemoglobin A,Carboxyhemoglobin C
D004305 Dose-Response Relationship, Drug The relationship between the dose of an administered drug and the response of the organism to the drug. Dose Response Relationship, Drug,Dose-Response Relationships, Drug,Drug Dose-Response Relationship,Drug Dose-Response Relationships,Relationship, Drug Dose-Response,Relationships, Drug Dose-Response

Related Publications

M R Carratù, and R Cagiano, and S Desantis, and M Labate, and M Tattoli, and L Trabace, and V Cuomo
Prenatal carbon monoxide exposure alters behavioral development.
January 1980, Neurobehavioral toxicology,
M R Carratù, and R Cagiano, and S Desantis, and M Labate, and M Tattoli, and L Trabace, and V Cuomo
Prenatal exposure to a low concentration of carbon monoxide disrupts hippocampal long-term potentiation in rat offspring.
August 2000, The Journal of pharmacology and experimental therapeutics,
M R Carratù, and R Cagiano, and S Desantis, and M Labate, and M Tattoli, and L Trabace, and V Cuomo
Effects of prenatal exposure to low concentrations of carbon monoxide on sexual behaviour and mesolimbic dopaminergic function in rat offspring.
October 1998, British journal of pharmacology,
M R Carratù, and R Cagiano, and S Desantis, and M Labate, and M Tattoli, and L Trabace, and V Cuomo
Prenatal reserpine exposure alters cardiovascular parameters in rat offspring.
November 1989, Fundamental and applied toxicology : official journal of the Society of Toxicology,
M R Carratù, and R Cagiano, and S Desantis, and M Labate, and M Tattoli, and L Trabace, and V Cuomo
Myelination changes in the rat optic nerve after prenatal exposure to methamphetamine.
August 2006, Brain research,
M R Carratù, and R Cagiano, and S Desantis, and M Labate, and M Tattoli, and L Trabace, and V Cuomo
Prenatal Exposure to Lipopolysaccharide Alters Renal DNA Methyltransferase Expression in Rat Offspring.
January 2017, PloS one,
M R Carratù, and R Cagiano, and S Desantis, and M Labate, and M Tattoli, and L Trabace, and V Cuomo
Prenatal exposure to carbon monoxide and vascular responsiveness of rat resistance vessels.
January 1996, Life sciences,
M R Carratù, and R Cagiano, and S Desantis, and M Labate, and M Tattoli, and L Trabace, and V Cuomo
Neurotoxicity of prenatal carbon monoxide exposure.
September 1987, Research report (Health Effects Institute),
M R Carratù, and R Cagiano, and S Desantis, and M Labate, and M Tattoli, and L Trabace, and V Cuomo
Low-level exposure to carbon monoxide.
August 2012, The British journal of general practice : the journal of the Royal College of General Practitioners,
M R Carratù, and R Cagiano, and S Desantis, and M Labate, and M Tattoli, and L Trabace, and V Cuomo
Chronic Exposure to Low-Dose Carbon Monoxide Alters Hemoglobin Mass and V˙O2max.
September 2020, Medicine and science in sports and exercise,
Copied contents to your clipboard!