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Biochemical mutants of Actinomyces griseus producing grisin were obtained under the action of chemical mutagens. The mutants were divided into 2 groups. The mutants with impaired synthesis of amino acids of the aspartic acid family, i.e. lysine, homoserine and methionine were included into the 1st group. The 2nd group included the mutants with impaired synthesis of the other amino acids, i.e. histidine, arginine, tyrosine, phenylalanine and valine. The antibiotic production level in the biochemical mutants was studied. It was found that the level of the antibiotic production was decreased in most of the biochemical mutants. A necessity for increased fonds of lysine and arginine for biosynthesis of grisin was shown.
V V Kuklin, and
L S Iustratova, and
V G Zhdanov
May 1975,
Antibiotiki,
V V Kuklin, and
L S Iustratova, and
V G Zhdanov
January 1977,
Mikrobiologiia,
V V Kuklin, and
L S Iustratova, and
V G Zhdanov
January 1982,
Zeitschrift fur allgemeine Mikrobiologie,
V V Kuklin, and
L S Iustratova, and
V G Zhdanov
October 1949,
Comptes rendus hebdomadaires des seances de l'Academie des sciences,
V V Kuklin, and
L S Iustratova, and
V G Zhdanov
December 1977,
Antibiotiki,
V V Kuklin, and
L S Iustratova, and
V G Zhdanov
December 1973,
Soviet genetics,
V V Kuklin, and
L S Iustratova, and
V G Zhdanov
May 1947,
Annales de l'Institut Pasteur,
V V Kuklin, and
L S Iustratova, and
V G Zhdanov
January 1975,
Antibiotiki,
V V Kuklin, and
L S Iustratova, and
V G Zhdanov
January 1971,
Nauchnye doklady vysshei shkoly. Biologicheskie nauki,
V V Kuklin, and
L S Iustratova, and
V G Zhdanov
June 1974,
Antibiotiki,
