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Potential antitumor agents. Part 29(1): synthesis and potential coanthracyclinic activity of imidazo[2,1-b]thiazole guanylhydrazones. 2000
A Andreani, and
A Leoni, and
A Locatelli, and
R Morigi, and
M Rambaldi, and
M Recanatini, and
V Garaliene
Dipartimento di Scienze Farmaceutiche, Università di Bologna, Italy. aldoandr@alma.unibo.it
This paper reports the synthesis of new imidazo[2,1-b]thiazole guanylhydrazones which were tested as potential antitumor agents. Three of these derivatives (those bearing a 3- or 4-nitrophenyl group) were the most potent and one of these showed a mild effect as CDK1 inhibitor. These same three derivatives were also tested as positive inotropic agents and two of them were more potent than amrinone at 10(-5) M. These two guanylhydrazones could be useful coanthracyclinic agents.
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