Biomaterial Database

Properties of derived cochlear action potentials in forward tonal masking in guinea pigs. 2000

Y A Al'tman, and N I Nikitin

I.P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg.

Chronic experiments on guinea pigs were used to study the characteristics of cochlear nerve action potentials and the derived potential in conditions of forward masking. The auditory nerve action potential was recorded from the round window of the cochlea. The derived potential was obtained by subtracting the action potential recorded with masking from the response obtained in silence. These studies showed that the derived potential showed higher sensitivity to masking than the traditional measure of masking, i.e., the decrement in the amplitude of the auditory nerve action potential. The derived potential reflects not only changes in the action potential during masking, but also changes in its shape. Differences between the derived potential and the action potential decrement provide evidence that the amplitude and time changes in the derived potential provide more complete information on the nature of activity in the auditory fibers.

UI	MeSH Term	Description	Entries
D010470	Perceptual Masking	The interference of one perceptual stimulus with another causing a decrease or lessening in perceptual effectiveness.	Masking, Perceptual,Maskings, Perceptual,Perceptual Maskings
D003051	Cochlea	The part of the inner ear (LABYRINTH) that is concerned with hearing. It forms the anterior part of the labyrinth, as a snail-like structure that is situated almost horizontally anterior to the VESTIBULAR LABYRINTH.	Cochleas
D003056	Cochlear Nerve	The cochlear part of the 8th cranial nerve (VESTIBULOCOCHLEAR NERVE). The cochlear nerve fibers originate from neurons of the SPIRAL GANGLION and project peripherally to cochlear hair cells and centrally to the cochlear nuclei (COCHLEAR NUCLEUS) of the BRAIN STEM. They mediate the sense of hearing.	Acoustic Nerve,Auditory Nerve,Acoustic Nerves,Auditory Nerves,Cochlear Nerves,Nerve, Acoustic,Nerve, Auditory,Nerve, Cochlear,Nerves, Acoustic,Nerves, Auditory,Nerves, Cochlear
D006168	Guinea Pigs	A common name used for the genus Cavia. The most common species is Cavia porcellus which is the domesticated guinea pig used for pets and biomedical research.	Cavia,Cavia porcellus,Guinea Pig,Pig, Guinea,Pigs, Guinea
D000200	Action Potentials	Abrupt changes in the membrane potential that sweep along the CELL MEMBRANE of excitable cells in response to excitation stimuli.	Spike Potentials,Nerve Impulses,Action Potential,Impulse, Nerve,Impulses, Nerve,Nerve Impulse,Potential, Action,Potential, Spike,Potentials, Action,Potentials, Spike,Spike Potential
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia