-transparent.png){kind=logo}
In the oxidation of benzo[alpha]pyrene in an abscorbic acid-ferrous sulphate-EDTA system, four dihydrodiols were detected. Three, trans-4,5-dihydro-4,5-dihydroxybenzo[alpha]pyrene, trans-7,8-dihydro-7,8-dihydroxybenzo[alpha]pyrene and trans-9,10-dihydro-9,10-dihydroxybenzo[alpha]pyrene were identified by their UV spectra and by direct comparisons of their chromatographic properties, using HPLC, with those of the authentic compounds. The fourth compound appeared to be trans-11,12-dihydro-11,12-dihydroxybenzo[alpha]pyrene since its ultraviolet spectrum was identical to that of the cis-dihydrodiol. Time-course experiments showed that the maximum amounts of products were obtained after 8 h of oxidation. A re-examination of the dihydrodiols formed from benzo[alpha]pyrene by rat-liver microsomal fractions failed to show the formation of the trans-11,12-dihydrodiol.
A Hewer, and
O Ribeiro, and
C Walsh, and
P L Grover, and
P Sims
July 1975,
Science (New York, N.Y.),
A Hewer, and
O Ribeiro, and
C Walsh, and
P L Grover, and
P Sims
June 1967,
Lancet (London, England),
A Hewer, and
O Ribeiro, and
C Walsh, and
P L Grover, and
P Sims
January 1957,
Comptes rendus des seances de la Societe de biologie et de ses filiales,
A Hewer, and
O Ribeiro, and
C Walsh, and
P L Grover, and
P Sims
May 1976,
Biochemical pharmacology,
A Hewer, and
O Ribeiro, and
C Walsh, and
P L Grover, and
P Sims
January 1949,
The Journal of investigative dermatology,
A Hewer, and
O Ribeiro, and
C Walsh, and
P L Grover, and
P Sims
May 1974,
The British journal of nutrition,
A Hewer, and
O Ribeiro, and
C Walsh, and
P L Grover, and
P Sims
November 1976,
British journal of cancer,
A Hewer, and
O Ribeiro, and
C Walsh, and
P L Grover, and
P Sims
January 1974,
Nutrition and metabolism,
A Hewer, and
O Ribeiro, and
C Walsh, and
P L Grover, and
P Sims
May 2008,
Huan jing ke xue= Huanjing kexue,
A Hewer, and
O Ribeiro, and
C Walsh, and
P L Grover, and
P Sims
July 1979,
Cancer letters,
