Biomaterial Database

Alendronate-related oral mucosa ulcerations. 2000

M A Gonzalez-Moles, and J V Bagan-Sebastian

School of Dentistry, University of Granada, Spain.

Alendronate is widely used in the treatment of osteoporosis and other bone diseases. Although it is considered a well-tolerated drug, there are numerous reports of adverse effects on the mucosa in the upper aerodigestive tract, with oesophagitis as the most common complication. The strict regulations for the proper administration of the drug indicate that these side effects might well be the result of a direct, irritant mechanism on the upper aerodigestive tract. We present two clinical cases of patients who developed extensive palatal ulcers as a result of taking alendronate. We discuss possible mechanisms implicated in the production of the ulcers and some clinical factors of interest.

UI	MeSH Term	Description	Entries
D008047	Lip Diseases	Diseases involving the LIP.	Disease, Lip,Diseases, Lip,Lip Disease
D009061	Mouth Mucosa	Lining of the ORAL CAVITY, including mucosa on the GUMS; the PALATE; the LIP; the CHEEK; floor of the mouth; and other structures. The mucosa is generally a nonkeratinized stratified squamous EPITHELIUM covering muscle, bone, or glands but can show varying degree of keratinization at specific locations.	Buccal Mucosa,Oral Mucosa,Mucosa, Mouth,Mucosa, Oral
D005260	Female		Females
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000368	Aged	A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available.	Elderly
D014060	Tongue Diseases	Diseases involving the TONGUE.	Microglossia,Disease, Tongue,Diseases, Tongue,Microglossias,Tongue Disease
D019226	Oral Ulcer	A loss of mucous substance of the mouth showing local excavation of the surface, resulting from the sloughing of inflammatory necrotic tissue. It is the result of a variety of causes, e.g., denture irritation, aphthous stomatitis (STOMATITIS, APHTHOUS); NOMA; necrotizing gingivitis (GINGIVITIS, NECROTIZING ULCERATIVE); TOOTHBRUSHING; and various irritants. (From Jablonski, Dictionary of Dentistry, 1992, p842)	Mouth Ulcer,Mouth Ulcers,Oral Ulcers,Ulcer, Mouth,Ulcer, Oral,Ulcers, Mouth,Ulcers, Oral
D019386	Alendronate	A nonhormonal medication for the treatment of postmenopausal osteoporosis in women. This drug builds healthy bone, restoring some of the bone loss as a result of osteoporosis.	4-Amino-1-Hydroxybutylidene 1,1-Biphosphonate,Alendronate Monosodium Salt, Trihydrate,Alendronate Sodium,Aminohydroxybutane Bisphosphonate,Fosamax,MK-217,MK 217,MK217
D021362	Palate, Hard	The anteriorly located rigid section of the PALATE.	Hard Palate,Palatine Bone,Bone, Palatine,Hard Palates,Palates, Hard