A case of granuloma caused by a foreign vegetal body (part of a thorn of Triticum vissosum) lodged in the subcutis of the perineum, observed at the Department of Surgical Symptomatology of Palermo is reported. The clinical case was of interest for the rarity of the way in which the foreign body reached the perineal tissues, the abnormal resulting clinical episode, and the histological finding. The intention is also to demonstrate how at times symptomatology and clinical objectivity are not always enough to guide the physician to correct diagnosis; where historical data are lacking, clinical objectivity, often suggest neoformation of heteroplastic type or aspecific chronic inflammation rather than granulomatous reactions due to foreign bodies.