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The present study investigated the effects of processed Aconiti tuber (TJ-3022, Tsumura-shuchi-bushi), a traditional herbal medicine (Kampo), on microcirculatory disturbances induced by endotoxin in the rat mesentery. The changes in arteriolar diameter, the velocity of red blood cells in arterioles and the venular microcirculation after endotoxin injection (6 mg/kg, iv) were observed using videomicroscopy. The mean arterial pressure and heart rate were monitored continuously during the experiments. TJ-3022 prevented significantly the decrease of mean arterial pressure, controlled the reduced velocity and apparently also inhibited leukocyte extravasation across venules. However, there were no significant changes in the arteriolar diameter and the heart rate between the groups treated with and without TJ-3022. The results indicate that processed Aconiti tuber (TJ-3022) has protective effects in improving microcirculatory disturbances induced by endotoxin in rat mesentery.
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