Prolonged QT interval and sudden infant death--report of two cases. 2001

T Bajanowski, and L Rossi, and B Biondo, and C Ortmann, and W Haverkamp, and H Wedekind, and G Jorch, and B Brinkmann
Institute of Legal Medicine, Westfälische Wilhelms-Universität, Von Esmarch-Strasse 62, D-48149 Münster, Germany.

In the two cases where infants died suddenly and unexpectedly the electrocardiogram (ECG) of a younger sibling (case 1) and of a living twin (case 2) led to the suspicion that the two infants could have died from long QT syndrome (LQTS). In case 1, a His bundle (HB) dispersion and a pronounced hypoplasia of the right external nucleus arcuatus were detected. In case 2, a severe interstitial pneumonia and an accompanying mild myocarditis were found by histology. Molecular genetic investigations of the coding regions of the genes, HERG, KVLQT1 and SCN5A gave no indication for the mutations, thus, affecting related myocardial ion channels as possible sources of inhomogeneity of repolarisation. Since a molecular genetic deviation could not yet be elaborated the possible role of related disturbance remains unknown.

UI MeSH Term Description Entries
D007223 Infant A child between 1 and 23 months of age. Infants
D008133 Long QT Syndrome A condition that is characterized by episodes of fainting (SYNCOPE) and varying degree of ventricular arrhythmia as indicated by the prolonged QT interval. The inherited forms are caused by mutation of genes encoding cardiac ion channel proteins. The two major forms are ROMANO-WARD SYNDROME and JERVELL-LANGE NIELSEN SYNDROME. Electrocardiogram QT Prolonged
D009154 Mutation Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations. Mutations
D009205 Myocarditis Inflammatory processes of the muscular walls of the heart (MYOCARDIUM) which result in injury to the cardiac muscle cells (MYOCYTES, CARDIAC). Manifestations range from subclinical to sudden death (DEATH, SUDDEN). Myocarditis in association with cardiac dysfunction is classified as inflammatory CARDIOMYOPATHY usually caused by INFECTION, autoimmune diseases, or responses to toxic substances. Myocarditis is also a common cause of DILATED CARDIOMYOPATHY and other cardiomyopathies. Carditis,Myocarditides
D011110 Polymorphism, Genetic The regular and simultaneous occurrence in a single interbreeding population of two or more discontinuous genotypes. The concept includes differences in genotypes ranging in size from a single nucleotide site (POLYMORPHISM, SINGLE NUCLEOTIDE) to large nucleotide sequences visible at a chromosomal level. Gene Polymorphism,Genetic Polymorphism,Polymorphism (Genetics),Genetic Polymorphisms,Gene Polymorphisms,Polymorphism, Gene,Polymorphisms (Genetics),Polymorphisms, Gene,Polymorphisms, Genetic
D002036 Bundle of His Small band of specialized CARDIAC MUSCLE fibers that originates in the ATRIOVENTRICULAR NODE and extends into the membranous part of the interventricular septum. The bundle of His, consisting of the left and the right bundle branches, conducts the electrical impulses to the HEART VENTRICLES in generation of MYOCARDIAL CONTRACTION. Atrioventricular Bundle,Anterior Fascicle,Kent-His Bundle,Left Bundle Branch of His,Posterior Fascicle,Right Bundle Branch of His,Atrioventricular Bundles,Bundle, Atrioventricular,Bundle, Kent-His,Bundles, Atrioventricular,Fascicle, Anterior,Fascicle, Posterior,His Bundle,Kent His Bundle
D002423 Cause of Death Factors which produce cessation of all vital bodily functions. They can be analyzed from an epidemiologic viewpoint. Causes of Death,Death Cause,Death Causes
D004200 Diseases in Twins Disorders affecting TWINS, one or both, at any age. Diseases in Twin,Twin, Diseases in,Twins, Diseases in,in Twin, Diseases,in Twins, Diseases
D004252 DNA Mutational Analysis Biochemical identification of mutational changes in a nucleotide sequence. Mutational Analysis, DNA,Analysis, DNA Mutational,Analyses, DNA Mutational,DNA Mutational Analyses,Mutational Analyses, DNA
D004562 Electrocardiography Recording of the moment-to-moment electromotive forces of the HEART as projected onto various sites on the body's surface, delineated as a scalar function of time. The recording is monitored by a tracing on slow moving chart paper or by observing it on a cardioscope, which is a CATHODE RAY TUBE DISPLAY. 12-Lead ECG,12-Lead EKG,12-Lead Electrocardiography,Cardiography,ECG,EKG,Electrocardiogram,Electrocardiograph,12 Lead ECG,12 Lead EKG,12 Lead Electrocardiography,12-Lead ECGs,12-Lead EKGs,12-Lead Electrocardiographies,Cardiographies,ECG, 12-Lead,EKG, 12-Lead,Electrocardiograms,Electrocardiographies, 12-Lead,Electrocardiographs,Electrocardiography, 12-Lead

Related Publications

T Bajanowski, and L Rossi, and B Biondo, and C Ortmann, and W Haverkamp, and H Wedekind, and G Jorch, and B Brinkmann
May 1991, Clinical cardiology,
T Bajanowski, and L Rossi, and B Biondo, and C Ortmann, and W Haverkamp, and H Wedekind, and G Jorch, and B Brinkmann
May 1979, Circulation,
T Bajanowski, and L Rossi, and B Biondo, and C Ortmann, and W Haverkamp, and H Wedekind, and G Jorch, and B Brinkmann
January 2021, Frontiers in pediatrics,
T Bajanowski, and L Rossi, and B Biondo, and C Ortmann, and W Haverkamp, and H Wedekind, and G Jorch, and B Brinkmann
October 1979, Archives of disease in childhood,
T Bajanowski, and L Rossi, and B Biondo, and C Ortmann, and W Haverkamp, and H Wedekind, and G Jorch, and B Brinkmann
September 1982, Circulation,
T Bajanowski, and L Rossi, and B Biondo, and C Ortmann, and W Haverkamp, and H Wedekind, and G Jorch, and B Brinkmann
April 1986, Archives of disease in childhood,
T Bajanowski, and L Rossi, and B Biondo, and C Ortmann, and W Haverkamp, and H Wedekind, and G Jorch, and B Brinkmann
April 1999, Pediatrics,
T Bajanowski, and L Rossi, and B Biondo, and C Ortmann, and W Haverkamp, and H Wedekind, and G Jorch, and B Brinkmann
July 1978, American journal of diseases of children (1960),
T Bajanowski, and L Rossi, and B Biondo, and C Ortmann, and W Haverkamp, and H Wedekind, and G Jorch, and B Brinkmann
December 1998, Journal of clinical pathology,
T Bajanowski, and L Rossi, and B Biondo, and C Ortmann, and W Haverkamp, and H Wedekind, and G Jorch, and B Brinkmann
January 1989, Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke,
Copied contents to your clipboard!