Randomised study of anastrozole versus tamoxifen as first-line therapy for advanced breast cancer in postmenopausal women. 2000

I Vergote, and J Bonneterre, and B Thürlimann, and J Robertson, and M Krzakowski, and L Mauriac, and L Koralewski, and A Webster, and M Steinberg, and M von Euler
Department Gynaecological Oncology, University Hospitals Leuven, Herestraat 49, B3000, Leuven, Belgium. ignance.vergote@uz.kuleuven.ac.be

A total of 668 patients (340 anastrozole and 328 tamoxifen) were randomised in a double-blind, double-dummy multicentre study. Anastrozole was given in a dose of 1 mg once daily and compared with tamoxifen 20 mg daily in postmenopausal patients with tumours that were hormone-receptor positive or of unknown receptor status. The efficacy and tolerability of anastrozole was compared with that of tamoxifen as first-line therapy for advanced breast cancer. The median time to progression was similar for both treatments (8.2 months in anastrozole patients and 8.3 months in tamoxifen patients). Anastrozole was also as effective as tamoxifen in terms of objective response-rate with 33% in the anastrozole group and 32.6% in the tamoxifen group achieving a complete or partial response. Both treatments were well tolerated. However, incidences of thromboembolic events and vaginal bleeding were reported in fewer patients treated with anastrozole than with tamoxifen. In conclusion, these findings indicate that anastrozole can be considered as first-line therapy for postmenopausal women with advanced breast cancer.

UI MeSH Term Description Entries
D009570 Nitriles Organic compounds containing the -CN radical. The concept is distinguished from CYANIDES, which denotes inorganic salts of HYDROGEN CYANIDE. Nitrile
D001943 Breast Neoplasms Tumors or cancer of the human BREAST. Breast Cancer,Breast Tumors,Cancer of Breast,Breast Carcinoma,Cancer of the Breast,Human Mammary Carcinoma,Malignant Neoplasm of Breast,Malignant Tumor of Breast,Mammary Cancer,Mammary Carcinoma, Human,Mammary Neoplasm, Human,Mammary Neoplasms, Human,Neoplasms, Breast,Tumors, Breast,Breast Carcinomas,Breast Malignant Neoplasm,Breast Malignant Neoplasms,Breast Malignant Tumor,Breast Malignant Tumors,Breast Neoplasm,Breast Tumor,Cancer, Breast,Cancer, Mammary,Cancers, Mammary,Carcinoma, Breast,Carcinoma, Human Mammary,Carcinomas, Breast,Carcinomas, Human Mammary,Human Mammary Carcinomas,Human Mammary Neoplasm,Human Mammary Neoplasms,Mammary Cancers,Mammary Carcinomas, Human,Neoplasm, Breast,Neoplasm, Human Mammary,Neoplasms, Human Mammary,Tumor, Breast
D004311 Double-Blind Method A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment. Double-Masked Study,Double-Blind Study,Double-Masked Method,Double Blind Method,Double Blind Study,Double Masked Method,Double Masked Study,Double-Blind Methods,Double-Blind Studies,Double-Masked Methods,Double-Masked Studies,Method, Double-Blind,Method, Double-Masked,Methods, Double-Blind,Methods, Double-Masked,Studies, Double-Blind,Studies, Double-Masked,Study, Double-Blind,Study, Double-Masked
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000077384 Anastrozole A nitrile and triazole derivative that acts as a selective nonsteroidal aromatase inhibitor. It is used in the treatment of ESTROGEN NUCLEAR RECEPTOR-positive breast cancer in postmenopausal women. 2,2'-(5-(1H-1,2,4-triazol-1-ylmethyl)-1,3-phenylene)bis(2-methylpropionitrile),Anastrazole,Arimidex,ICI D1033,ZD-1033,ZD1033,Zeneca ZD 1033,ZD 1033
D013629 Tamoxifen One of the SELECTIVE ESTROGEN RECEPTOR MODULATORS with tissue-specific activities. Tamoxifen acts as an anti-estrogen (inhibiting agent) in the mammary tissue, but as an estrogen (stimulating agent) in cholesterol metabolism, bone density, and cell proliferation in the ENDOMETRIUM. ICI-46,474,ICI-46474,ICI-47699,Nolvadex,Novaldex,Soltamox,Tamoxifen Citrate,Tomaxithen,Zitazonium,Citrate, Tamoxifen,ICI 46,474,ICI 46474,ICI 47699,ICI46,474,ICI46474,ICI47699
D014230 Triazoles Heterocyclic compounds containing a five-membered ring with two carbon atoms and three nitrogen atoms with the molecular formula C2H3N3. Triazole
D017698 Postmenopause The physiological period following the MENOPAUSE, the permanent cessation of the menstrual life. Post-Menopause,Post-menopausal Period,Postmenopausal Period,Period, Post-menopausal,Period, Postmenopausal,Post Menopause,Post menopausal Period,Post-Menopauses
D018931 Antineoplastic Agents, Hormonal Antineoplastic agents that are used to treat hormone-sensitive tumors. Hormone-sensitive tumors may be hormone-dependent, hormone-responsive, or both. A hormone-dependent tumor regresses on removal of the hormonal stimulus, by surgery or pharmacological block. Hormone-responsive tumors may regress when pharmacologic amounts of hormones are administered regardless of whether previous signs of hormone sensitivity were observed. The major hormone-responsive cancers include carcinomas of the breast, prostate, and endometrium; lymphomas; and certain leukemias. (From AMA Drug Evaluations Annual 1994, p2079) Hormonal Antineoplastic Agents,Antineoplastic Drugs, Hormonal,Antineoplastic Hormonal Agents,Antineoplastic Hormonal Drugs,Antineoplastics, Hormonal,Hormonal Agents, Antineoplastic,Hormonal Antineoplastic Drugs,Hormonal Antineoplastics,Agents, Antineoplastic Hormonal,Drugs, Antineoplastic Hormonal,Hormonal Drugs, Antineoplastic

Related Publications

I Vergote, and J Bonneterre, and B Thürlimann, and J Robertson, and M Krzakowski, and L Mauriac, and L Koralewski, and A Webster, and M Steinberg, and M von Euler
November 2003, Clinical therapeutics,
I Vergote, and J Bonneterre, and B Thürlimann, and J Robertson, and M Krzakowski, and L Mauriac, and L Koralewski, and A Webster, and M Steinberg, and M von Euler
September 2002, Journal of clinical oncology : official journal of the American Society of Clinical Oncology,
I Vergote, and J Bonneterre, and B Thürlimann, and J Robertson, and M Krzakowski, and L Mauriac, and L Koralewski, and A Webster, and M Steinberg, and M von Euler
May 2001, Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al],
I Vergote, and J Bonneterre, and B Thürlimann, and J Robertson, and M Krzakowski, and L Mauriac, and L Koralewski, and A Webster, and M Steinberg, and M von Euler
August 2003, European journal of cancer (Oxford, England : 1990),
I Vergote, and J Bonneterre, and B Thürlimann, and J Robertson, and M Krzakowski, and L Mauriac, and L Koralewski, and A Webster, and M Steinberg, and M von Euler
November 2003, European journal of cancer (Oxford, England : 1990),
I Vergote, and J Bonneterre, and B Thürlimann, and J Robertson, and M Krzakowski, and L Mauriac, and L Koralewski, and A Webster, and M Steinberg, and M von Euler
May 2001, Journal of clinical oncology : official journal of the American Society of Clinical Oncology,
I Vergote, and J Bonneterre, and B Thürlimann, and J Robertson, and M Krzakowski, and L Mauriac, and L Koralewski, and A Webster, and M Steinberg, and M von Euler
May 2001, Journal of clinical oncology : official journal of the American Society of Clinical Oncology,
I Vergote, and J Bonneterre, and B Thürlimann, and J Robertson, and M Krzakowski, and L Mauriac, and L Koralewski, and A Webster, and M Steinberg, and M von Euler
May 2001, Journal of clinical oncology : official journal of the American Society of Clinical Oncology,
I Vergote, and J Bonneterre, and B Thürlimann, and J Robertson, and M Krzakowski, and L Mauriac, and L Koralewski, and A Webster, and M Steinberg, and M von Euler
May 2001, Journal of clinical oncology : official journal of the American Society of Clinical Oncology,
I Vergote, and J Bonneterre, and B Thürlimann, and J Robertson, and M Krzakowski, and L Mauriac, and L Koralewski, and A Webster, and M Steinberg, and M von Euler
May 2001, Journal of clinical oncology : official journal of the American Society of Clinical Oncology,
Copied contents to your clipboard!