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The in-vitro activity of nalidixic acid and pipemidic acid was investigated in a combined study in 450 freshly isolated bacterial strains using the agar dilution test. Gram-positive cocci were resistant to both substances except for a few pipemidic acid sensitive staphylococci. Both substances had good antibacterial activity in the gram-negative spectrum. However, the MIC values of pipemidic acid were generally clearly lower than those of nalidixic acid. Only pipemidic acid showed activity against Pseudomonas aeruginosa. Thus the in-vitro results showed that pipemidic acid has clear-cut and valuable advantages for the treatment of urinary tract infections when compared with nalidixic acid.
G Peters, and
H Freiesleben, and
R Marre, and
H Metz, and
H Tannenberg, and
G Pulverer
January 1982,
Annali dell'Istituto superiore di sanita,
G Peters, and
H Freiesleben, and
R Marre, and
H Metz, and
H Tannenberg, and
G Pulverer
June 1968,
Antibiotica,
G Peters, and
H Freiesleben, and
R Marre, and
H Metz, and
H Tannenberg, and
G Pulverer
August 1980,
Die Medizinische Welt,
G Peters, and
H Freiesleben, and
R Marre, and
H Metz, and
H Tannenberg, and
G Pulverer
June 1983,
European journal of clinical microbiology,
G Peters, and
H Freiesleben, and
R Marre, and
H Metz, and
H Tannenberg, and
G Pulverer
August 1979,
The Japanese journal of antibiotics,
G Peters, and
H Freiesleben, and
R Marre, and
H Metz, and
H Tannenberg, and
G Pulverer
July 1990,
Mikrobiyoloji bulteni,
G Peters, and
H Freiesleben, and
R Marre, and
H Metz, and
H Tannenberg, and
G Pulverer
January 1984,
Antimicrobial agents and chemotherapy,
G Peters, and
H Freiesleben, and
R Marre, and
H Metz, and
H Tannenberg, and
G Pulverer
May 1975,
Il Farmaco; edizione pratica,
G Peters, and
H Freiesleben, and
R Marre, and
H Metz, and
H Tannenberg, and
G Pulverer
January 1973,
Antibiotica,
G Peters, and
H Freiesleben, and
R Marre, and
H Metz, and
H Tannenberg, and
G Pulverer
December 1983,
Methods and findings in experimental and clinical pharmacology,
