-transparent.png){kind=logo}
A series of azolylmethyloxolane derivatives with modified sterol side-chain structures, designed as potential dual functional inhibitors of cytochrome P450 14alpha-demethylase (14DM) and delta24-sterol methyltransferase (24-SMT) based on the common characteristic features of 24-aminosterols and azole antifungal agents, were synthesized and evaluated for their antifungal activities and inhibitory activities of 14DM and 24-SMT. Among these compounds, imidazolylmethyloxolane derivatives 28a and 28b showed potent in vitro antifungal activities comparable to those of itraconazole. However, the in vitro bioactivities have not been linearly translated into in vivo protection data for some unknown reasons.
S K Chung, and
K W Lee, and
H I Kang, and
C Yamashita, and
M Kudo, and
Y Yoshida
January 1989,
The Italian journal of biochemistry,
S K Chung, and
K W Lee, and
H I Kang, and
C Yamashita, and
M Kudo, and
Y Yoshida
February 1990,
Biochemical Society transactions,
S K Chung, and
K W Lee, and
H I Kang, and
C Yamashita, and
M Kudo, and
Y Yoshida
October 2019,
Journal of agricultural and food chemistry,
S K Chung, and
K W Lee, and
H I Kang, and
C Yamashita, and
M Kudo, and
Y Yoshida
January 1995,
Acta biochimica Polonica,
S K Chung, and
K W Lee, and
H I Kang, and
C Yamashita, and
M Kudo, and
Y Yoshida
January 2017,
Chemical & pharmaceutical bulletin,
S K Chung, and
K W Lee, and
H I Kang, and
C Yamashita, and
M Kudo, and
Y Yoshida
November 2021,
Molecules (Basel, Switzerland),
S K Chung, and
K W Lee, and
H I Kang, and
C Yamashita, and
M Kudo, and
Y Yoshida
February 2015,
Amino acids,
S K Chung, and
K W Lee, and
H I Kang, and
C Yamashita, and
M Kudo, and
Y Yoshida
February 2023,
Molecular diversity,
S K Chung, and
K W Lee, and
H I Kang, and
C Yamashita, and
M Kudo, and
Y Yoshida
April 2021,
Bioorganic & medicinal chemistry,
S K Chung, and
K W Lee, and
H I Kang, and
C Yamashita, and
M Kudo, and
Y Yoshida
November 2001,
Bioorganic & medicinal chemistry letters,
