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The influence of 7-chloro-1,3-dihydro-3-hydroxy-5-phenyl 2H-1,4-benzodiazepin-2-one (oxazepam, Adumbran) (30 mg) on the effects produced by alcohol (0.75 g/kg) and vice versa was studied in 14 male test subjects using the following scheme: (A) alcohol; (B) placebo; (C) oxazepam; (D) oxazepam and alcohol combined; (E) alcohol given 30 min prior to oxazepam. Blood and serum levels were determined and excretion in the urine was tested during the 7-h duration of the experiment. The blood alcohol curves show a similar course, leading to the conclusion that oxazepam has no influence on the elimination of alcohol. Alcohol retrads the intestinal absorption of oxazepam but, on the other hand, does not show an effect on the specific metabolism of oxazepam.
H J Mallach, and
A Moosmayer, and
K Gottwald, and
M Staak
December 1979,
The Japanese journal of antibiotics,
H J Mallach, and
A Moosmayer, and
K Gottwald, and
M Staak
January 1981,
Arzneimittel-Forschung,
H J Mallach, and
A Moosmayer, and
K Gottwald, and
M Staak
October 1980,
The Japanese journal of antibiotics,
H J Mallach, and
A Moosmayer, and
K Gottwald, and
M Staak
February 1975,
The Japanese journal of antibiotics,
H J Mallach, and
A Moosmayer, and
K Gottwald, and
M Staak
July 1976,
The Japanese journal of antibiotics,
H J Mallach, and
A Moosmayer, and
K Gottwald, and
M Staak
December 1978,
The Japanese journal of antibiotics,
H J Mallach, and
A Moosmayer, and
K Gottwald, and
M Staak
September 1976,
The Japanese journal of antibiotics,
H J Mallach, and
A Moosmayer, and
K Gottwald, and
M Staak
January 1976,
Arzneimittel-Forschung,
H J Mallach, and
A Moosmayer, and
K Gottwald, and
M Staak
June 1975,
The Japanese journal of antibiotics,
H J Mallach, and
A Moosmayer, and
K Gottwald, and
M Staak
April 1974,
The Japanese journal of antibiotics,
