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The aim of this study was to develop a method of semi-automated 6-[18F]fluoro-L-dopa (6-[18F]FDOPA) synthesis using a robotic system (Scanditronix Anatech RB III, Uppsala, Sweden). [18F]Fluorine was produced via 20Ne(d,alpha)18F using a Scanditronix MC17F cyclotron (Uppsala). The radiosynthesis was performed by the Scanditronix Anatech RB III robotic system. On average, a typical run produced 16-19 mCi of 6-[18F]FDOPA at end of synthesis (EOS) after 2 h irradiation of the F2/neon gas target. The total synthesis time was 110 min. The retention time of 6-[18F]FDOPA (the radio peak) was 8.2 min, which was consistent with the 6-[19F]FDOPA ultraviolet peak. The radiochemical purity was greater than 97%. A robotic, semi-automated method for 6-[18F]FDOPA radiosynthesis is therefore feasible. The radiation burden for the operator can be reduced as much as possible. Sufficient activity of 6-[18F]FDOPA could be obtained for positron emission tomography studies of dopaminergic function.
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C S Chtsai, and
J B Chen, and
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March 1986,
Journal of nuclear medicine : official publication, Society of Nuclear Medicine,
C W Chang, and
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H M Lin, and
C S Chtsai, and
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R S Liu
March 2021,
EJNMMI radiopharmacy and chemistry,
C W Chang, and
H E Wang, and
H M Lin, and
C S Chtsai, and
J B Chen, and
R S Liu
December 1986,
Journal of nuclear medicine : official publication, Society of Nuclear Medicine,
C W Chang, and
H E Wang, and
H M Lin, and
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May 2003,
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine,
C W Chang, and
H E Wang, and
H M Lin, and
C S Chtsai, and
J B Chen, and
R S Liu
March 1999,
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism,
C W Chang, and
H E Wang, and
H M Lin, and
C S Chtsai, and
J B Chen, and
R S Liu
August 2002,
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine,
C W Chang, and
H E Wang, and
H M Lin, and
C S Chtsai, and
J B Chen, and
R S Liu
January 1996,
Nuclear medicine and biology,
C W Chang, and
H E Wang, and
H M Lin, and
C S Chtsai, and
J B Chen, and
R S Liu
November 1984,
Journal of nuclear medicine : official publication, Society of Nuclear Medicine,
C W Chang, and
H E Wang, and
H M Lin, and
C S Chtsai, and
J B Chen, and
R S Liu
May 2021,
EJNMMI radiopharmacy and chemistry,
C W Chang, and
H E Wang, and
H M Lin, and
C S Chtsai, and
J B Chen, and
R S Liu
March 1988,
Journal of nuclear medicine : official publication, Society of Nuclear Medicine,
