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This in vivo study assessed the immediate effects of insulin on glucose and ketone body utilization in the fed, fasted, and diabetic ketoacidotic rat. The experimental design consisted of the functional removal of the liver (the site of glucose and ketone body production) and the pancreas from the anesthetized animals. This surgical procedure permitted the assessment of the effect of exogenously administered insulin on the rate of both glucose and ketone body utilization by peripheral tissues. Insulin exerted hypoglycemic activity in all three metabolic states studied. This hypoglycemic activity contrasted to the lack of demonstrable effect of this hormone on ketone body uptake by peripheral tissues. It was concluded that in the rat, the immediate effect of insulin, i.e. within 30 minutes, was to exert hypoglycemic activity without simultaneous hypoketoniemic activity.
C M Herndon, and
D S Schade, and
R P Eaton
October 1987,
Pediatric research,
C M Herndon, and
D S Schade, and
R P Eaton
April 1964,
The Journal of clinical investigation,
C M Herndon, and
D S Schade, and
R P Eaton
September 1979,
Revista espanola de fisiologia,
C M Herndon, and
D S Schade, and
R P Eaton
July 1986,
The Journal of clinical endocrinology and metabolism,
C M Herndon, and
D S Schade, and
R P Eaton
July 1984,
The Journal of clinical investigation,
C M Herndon, and
D S Schade, and
R P Eaton
November 1989,
Metabolism: clinical and experimental,
C M Herndon, and
D S Schade, and
R P Eaton
September 1973,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
C M Herndon, and
D S Schade, and
R P Eaton
September 1983,
Nutrition reviews,
C M Herndon, and
D S Schade, and
R P Eaton
April 1971,
The Journal of clinical investigation,
C M Herndon, and
D S Schade, and
R P Eaton
September 1970,
The Journal of clinical investigation,
