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Synthesis of coumarins via palladium-catalyzed carbonylative annulation of internal alkynes by o-iodophenols 2000

Kadnikov, and Larock
Department of Chemistry, Iowa State University, Ames, Iowa 50011, USA.

A variety of substituted coumarins have been prepared in good yields by the palladium-catalyzed coupling of o-iodophenols with internal alkynes and 1 atm of carbon monoxide. Unlike most of the previous work on the palladium-catalyzed carbonylation of alkynes, the insertion of the internal alkyne occurs in preference to the insertion of CO.

UI MeSH Term Description Entries

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