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Factor VIII-related antigen and its low ionic strength subunits were demonstrated in endothelium and hemostatic plugs obtained from punch biopsies of bleeding time wounds according to Mielke. No IgG, IgA, IgM, C4-C3, albumin, or prothrombin was demonstrated in the cryostat sections of hemostatic plugs. Antifibrinogen stained the hemostatic plug and fibrin fibers along the edges of the skin wound. Antiplatelet actomyosin stained the hemostatic plug and the endothelium and pericytes of blood vessels. These results suggest that factor VIII is present in the hemostatic plug not by trapping of plasma but by close association with or presence within the blood platelets. The positive staining of a hemostatic plug in which most platelets have undergone the release reaction indicates that antifactor VIII may be useful for the detection of platelet thrombi in tissue of patients with suspected diffuse intravascular coagulation.
J J Sixma, and
L Kater, and
B N Bouma, and
F Schmitz du Moulin, and
S De Graaf, and
G Tuit
November 1978,
Thrombosis research,
J J Sixma, and
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B N Bouma, and
F Schmitz du Moulin, and
S De Graaf, and
G Tuit
April 1978,
Clinical immunology and immunopathology,
J J Sixma, and
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F Schmitz du Moulin, and
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G Tuit
June 1985,
Diabete & metabolisme,
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B N Bouma, and
F Schmitz du Moulin, and
S De Graaf, and
G Tuit
May 1974,
The Journal of clinical investigation,
J J Sixma, and
L Kater, and
B N Bouma, and
F Schmitz du Moulin, and
S De Graaf, and
G Tuit
January 1974,
Haemostasis,
J J Sixma, and
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B N Bouma, and
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May 1980,
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The Histochemical journal,
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April 1993,
Journal of the National Cancer Institute,
J J Sixma, and
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F Schmitz du Moulin, and
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G Tuit
July 1978,
European journal of pediatrics,
J J Sixma, and
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F Schmitz du Moulin, and
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G Tuit
December 1975,
Proceedings of the National Academy of Sciences of the United States of America,
