BIOMAT Database Logo BIOMAT Database Logo

Telomere shortening with aging in human liver. 2000

K Takubo, and K Nakamura, and N Izumiyama, and E Furugori, and M Sawabe, and T Arai, and Y Esaki, and K Mafune, and M Kammori, and M Fujiwara, and M Kato, and M Oshimura, and K Sasajima
Department of Clinical Pathology, Tokyo Metropolitan Institute of Gerontology, Japan. takubo@tmig.or.jp

Progressive telomere shortening with aging was studied in the normal liver tissue of 94 human subjects aged between 0 and 101 years old to determine the rate of telomere loss in 1 year. Telomere length demonstrated accelerated shortening with reduction of 55 base pairs (bp) per year. The mean telomere length in five neonates was 12.9 +/- 2.6 kilobase pairs (kbp), and that in one centenarian was 8.3 kbp. Mean telomere lengths by age group were 13.2 +/- 2.0 kbp (< or = 8 years; 10 subjects), 7.8 +/- 1.9 kbp (40-79 years; 29 subjects), and 7.5 +/- 2.0 kbp (> or = 80 years; 53 subjects), with reduction thus appearing to show slowing on the attainment of middle age. The difference of mean telomere lengths for two groups with or without advanced malignancies of other than liver origin was not significant in the older two groups. Despite the slow turnover of liver tissue, the overall reduction rate of telomere length decrease in 1 year was almost the same as that of digestive tract mucosa, with its very rapid renewal.

UI MeSH Term Description Entries
D007223 Infant A child between 1 and 23 months of age. Infants
D007231 Infant, Newborn An infant during the first 28 days after birth. Neonate,Newborns,Infants, Newborn,Neonates,Newborn,Newborn Infant,Newborn Infants
D008099 Liver A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances. Livers
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D002648 Child A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL. Children
D002675 Child, Preschool A child between the ages of 2 and 5. Children, Preschool,Preschool Child,Preschool Children
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000293 Adolescent A person 13 to 18 years of age. Adolescence,Youth,Adolescents,Adolescents, Female,Adolescents, Male,Teenagers,Teens,Adolescent, Female,Adolescent, Male,Female Adolescent,Female Adolescents,Male Adolescent,Male Adolescents,Teen,Teenager,Youths

Related Publications

K Takubo, and K Nakamura, and N Izumiyama, and E Furugori, and M Sawabe, and T Arai, and Y Esaki, and K Mafune, and M Kammori, and M Fujiwara, and M Kato, and M Oshimura, and K Sasajima
Response to "telomere shortening with aging in human liver".
June 2001, The journals of gerontology. Series A, Biological sciences and medical sciences,
K Takubo, and K Nakamura, and N Izumiyama, and E Furugori, and M Sawabe, and T Arai, and Y Esaki, and K Mafune, and M Kammori, and M Fujiwara, and M Kato, and M Oshimura, and K Sasajima
Telomere shortening in chronic liver diseases.
June 1995, Biochemical and biophysical research communications,
K Takubo, and K Nakamura, and N Izumiyama, and E Furugori, and M Sawabe, and T Arai, and Y Esaki, and K Mafune, and M Kammori, and M Fujiwara, and M Kato, and M Oshimura, and K Sasajima
Telomere shortening in human diseases.
July 2013, The FEBS journal,
K Takubo, and K Nakamura, and N Izumiyama, and E Furugori, and M Sawabe, and T Arai, and Y Esaki, and K Mafune, and M Kammori, and M Fujiwara, and M Kato, and M Oshimura, and K Sasajima
Telomere Shortening and Accelerated Aging in US Military Veterans.
February 2021, International journal of environmental research and public health,
K Takubo, and K Nakamura, and N Izumiyama, and E Furugori, and M Sawabe, and T Arai, and Y Esaki, and K Mafune, and M Kammori, and M Fujiwara, and M Kato, and M Oshimura, and K Sasajima
Telomere shortening may be associated with human keloids.
October 2009, BMC medical genetics,
K Takubo, and K Nakamura, and N Izumiyama, and E Furugori, and M Sawabe, and T Arai, and Y Esaki, and K Mafune, and M Kammori, and M Fujiwara, and M Kato, and M Oshimura, and K Sasajima
Telomere shortening is a sole mechanism of aging in mammals.
December 2012, Current aging science,
K Takubo, and K Nakamura, and N Izumiyama, and E Furugori, and M Sawabe, and T Arai, and Y Esaki, and K Mafune, and M Kammori, and M Fujiwara, and M Kato, and M Oshimura, and K Sasajima
The aging lung: tissue telomere shortening in health and disease.
May 2018, Respiratory research,
K Takubo, and K Nakamura, and N Izumiyama, and E Furugori, and M Sawabe, and T Arai, and Y Esaki, and K Mafune, and M Kammori, and M Fujiwara, and M Kato, and M Oshimura, and K Sasajima
Telomere shortening in human coronary artery diseases.
March 2004, Arteriosclerosis, thrombosis, and vascular biology,
K Takubo, and K Nakamura, and N Izumiyama, and E Furugori, and M Sawabe, and T Arai, and Y Esaki, and K Mafune, and M Kammori, and M Fujiwara, and M Kato, and M Oshimura, and K Sasajima
Abrupt telomere shortening in normal human fibroblasts.
March 2010, Experimental gerontology,
K Takubo, and K Nakamura, and N Izumiyama, and E Furugori, and M Sawabe, and T Arai, and Y Esaki, and K Mafune, and M Kammori, and M Fujiwara, and M Kato, and M Oshimura, and K Sasajima
Telomere shortening does not occur during postmaturational aging in situ in normal human oral fibroblasts.
January 2003, Mechanisms of ageing and development,
Copied contents to your clipboard!