The authors present an analysis of clinical and pathomorphological findings in 48 cases of malignant neoplasms of the epipharynx. The immediate and late results obtained in radiation, associated radiation and combined therapy are discussed. As a result of the conducted investigation, it was concluded that, while planning a distant radiotherapy, it is essential to take into account the histomorphology, and extent of local and regional spread of malignant epipharyngeal tumor. It is felt that 6000 rads is an optimum absorbed dose in the primary focus and regional metastases. A specific method of an associated radiotherapy for epipharyngeal neoplasms, including distant gammatherapy of the primary focus and lymph outflow routes, and irradiation with fast electrons (15 Mev) to zones of regional metastases is described.