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100 patients were treated either with heparin 5,000 i.u. every 12 hours or placebo in a double-blind, randomized, prospective trial. The treatment was commenced 1-3 hours before surgery and was continued for 6 1/2 days. The criteria for the selection of patients and the principles on which the treatment and investigation schedules were based corresponded generally to those laid down by Kakkar et al. (1972). The incidence of deep-vein thrombosis of the lower extremities was 6% in the group treated with heparin and 20% in the placebo group. The decisive diagnosis of thrombosis was based on the scanning of the lower extremities after administration of I125-fibrinogen. No case of pulmonary embolism occurred and no complications because of the treatment were noted. We propose to institute investigations on a larger scale to evaluate the prophylactic value of small heparin doses with respect to pulmonary embolism.
L Strand, and
O K Bank-Mikkelsen, and
H Lindewald
November 1972,
The British journal of surgery,
L Strand, and
O K Bank-Mikkelsen, and
H Lindewald
January 1984,
Canadian journal of surgery. Journal canadien de chirurgie,
L Strand, and
O K Bank-Mikkelsen, and
H Lindewald
January 2010,
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis,
L Strand, and
O K Bank-Mikkelsen, and
H Lindewald
September 1974,
Orvosi hetilap,
L Strand, and
O K Bank-Mikkelsen, and
H Lindewald
October 1972,
Lancet (London, England),
L Strand, and
O K Bank-Mikkelsen, and
H Lindewald
October 1977,
Lancet (London, England),
L Strand, and
O K Bank-Mikkelsen, and
H Lindewald
February 1988,
JAMA,
L Strand, and
O K Bank-Mikkelsen, and
H Lindewald
July 1997,
British journal of anaesthesia,
L Strand, and
O K Bank-Mikkelsen, and
H Lindewald
January 1974,
Duodecim; laaketieteellinen aikakauskirja,
L Strand, and
O K Bank-Mikkelsen, and
H Lindewald
January 1987,
JAMA,
