BIOMAT Database Logo BIOMAT Database Logo

Response to varicella immunization in pediatric liver transplant recipients. 2000

M Donati, and M Zuckerman, and A Dhawan, and N Hadzic, and N Heaton, and P North-Lewis, and G Mieli-Vergani
Department of Virology, Guy's King's and St Thomas' School of Medicine, King's College Hospital, Dulwich, London, United Kingdom.

BACKGROUND Individuals undergoing therapeutic immunosuppression are at risk of severe varicella-zoster virus (VZV) infection, particularly those without evidence of previous infection. METHODS Eleven children, median age 10 months (range 5.5 months to 7 years and 9 months) received one dose of varicella vaccine (Varilrix, SmithKline Beecham plc, UK) before liver transplantation (median interval 95 days, range 40-289 days). The serological response to varicella vaccine was evaluated retrospectively and matched with the outcome and management of any subsequent exposures to VZV. RESULTS Three children responded postimmunization, six children showed no response, and in two children the outcome was difficult to interpret having received blood products. Four children required varicella-zoster immunoglobulin prophylaxis posttransplantation, two of whom developed mild chickenpox. CONCLUSIONS Only 3 of 11 children developed a clear antibody response to varicella vaccine. Administration of varicella vaccine did not affect the management of subsequent VZV exposures.

UI MeSH Term Description Entries
D007114 Immunization Deliberate stimulation of the host's immune response. ACTIVE IMMUNIZATION involves administration of ANTIGENS or IMMUNOLOGIC ADJUVANTS. PASSIVE IMMUNIZATION involves administration of IMMUNE SERA or LYMPHOCYTES or their extracts (e.g., transfer factor, immune RNA) or transplantation of immunocompetent cell producing tissue (thymus or bone marrow). Immunologic Stimulation,Immunostimulation,Sensitization, Immunologic,Variolation,Immunologic Sensitization,Immunological Stimulation,Sensitization, Immunological,Stimulation, Immunologic,Immunizations,Immunological Sensitization,Immunological Sensitizations,Immunological Stimulations,Sensitizations, Immunological,Stimulation, Immunological,Stimulations, Immunological,Variolations
D007223 Infant A child between 1 and 23 months of age. Infants
D002644 Chickenpox A highly contagious infectious disease caused by the varicella-zoster virus (HERPESVIRUS 3, HUMAN). It usually affects children, is spread by direct contact or respiratory route via droplet nuclei, and is characterized by the appearance on the skin and mucous membranes of successive crops of typical pruritic vesicular lesions that are easily broken and become scabbed. Chickenpox is relatively benign in children, but may be complicated by pneumonia and encephalitis in adults. (From Dorland, 27th ed) Varicella,Chicken Pox
D002648 Child A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL. Children
D002675 Child, Preschool A child between the ages of 2 and 5. Children, Preschool,Preschool Child,Preschool Children
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000917 Antibody Formation The production of ANTIBODIES by proliferating and differentiated B-LYMPHOCYTES under stimulation by ANTIGENS. Antibody Production,Antibody Response,Antibody Responses,Formation, Antibody,Production, Antibody,Response, Antibody,Responses, Antibody
D016031 Liver Transplantation The transference of a part of or an entire liver from one human or animal to another. Grafting, Liver,Hepatic Transplantation,Liver Transplant,Transplantation, Hepatic,Transplantation, Liver,Hepatic Transplantations,Liver Grafting,Liver Transplantations,Liver Transplants,Transplant, Liver
D019433 Chickenpox Vaccine A live, attenuated varicella virus vaccine used for immunization against chickenpox. It is recommended for children between the ages of 12 months and 13 years. Oka Varicella Vaccine,Varicella Vaccine,Varivax,Vaccine, Chickenpox,Vaccine, Oka Varicella,Vaccine, Varicella,Varicella Vaccine, Oka

Related Publications

M Donati, and M Zuckerman, and A Dhawan, and N Hadzic, and N Heaton, and P North-Lewis, and G Mieli-Vergani
Varicella-zoster immunization in pediatric liver transplant recipients: safe and immunogenic.
November 2012, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons,
M Donati, and M Zuckerman, and A Dhawan, and N Hadzic, and N Heaton, and P North-Lewis, and G Mieli-Vergani
Long-term Seroprotection of Varicella-zoster Immunization in Pediatric Liver Transplant Recipients.
November 2019, Transplantation,
M Donati, and M Zuckerman, and A Dhawan, and N Hadzic, and N Heaton, and P North-Lewis, and G Mieli-Vergani
Varicella in pediatric orthotopic liver transplant recipients.
February 1989, Pediatrics,
M Donati, and M Zuckerman, and A Dhawan, and N Hadzic, and N Heaton, and P North-Lewis, and G Mieli-Vergani
Varicella in pediatric renal transplant recipients.
August 1992, Pediatrics,
M Donati, and M Zuckerman, and A Dhawan, and N Hadzic, and N Heaton, and P North-Lewis, and G Mieli-Vergani
Sustainability of humoral responses to varicella vaccine in pediatric transplant recipients following a pretransplantation immunization strategy.
December 2009, Pediatric transplantation,
M Donati, and M Zuckerman, and A Dhawan, and N Hadzic, and N Heaton, and P North-Lewis, and G Mieli-Vergani
Antibody response to influenza vaccine in pediatric liver transplant recipients.
June 2011, The Pediatric infectious disease journal,
M Donati, and M Zuckerman, and A Dhawan, and N Hadzic, and N Heaton, and P North-Lewis, and G Mieli-Vergani
Varicella-zoster infections in pediatric renal transplant recipients.
June 1980, Archives of surgery (Chicago, Ill. : 1960),
M Donati, and M Zuckerman, and A Dhawan, and N Hadzic, and N Heaton, and P North-Lewis, and G Mieli-Vergani
Antibody response of pediatric solid organ transplant recipients to immunization against influenza virus.
December 1995, The Journal of pediatrics,
M Donati, and M Zuckerman, and A Dhawan, and N Hadzic, and N Heaton, and P North-Lewis, and G Mieli-Vergani
An economic evaluation of varicella vaccine for pediatric liver and kidney transplant recipients.
September 1993, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America,
M Donati, and M Zuckerman, and A Dhawan, and N Hadzic, and N Heaton, and P North-Lewis, and G Mieli-Vergani
Bacteremia in Pediatric Liver Transplant Recipients.
August 2023, The Pediatric infectious disease journal,
Copied contents to your clipboard!