-transparent.png){kind=logo}
To define the minimal inhibitory concentration (MIC) of dapsone (DDS) for Mycobacterium leprae in rats, we determined the relationship between dietary and plasma levels of DDS in uninfected male and female Lewis rats. This knowledge was applied to the design of experiments using rats inoculated in the footpads with M. leprae. The MIC for DDS in male and female rats, respectively, was 1.5 to 4.0 ng and 1.8 to 3.0 ng of DDS/ml of plasma, even though the sexes exhibited markedly different concentrations of DDS when receiving the same dietary level of DDS. These values for the MIC of DDS for M. leprae in rats are nearly identical to the previously determined MIC of DDS for M. leprae in mice.
J H Peters, and
G R Gordon, and
J F Murray, and
A H Fieldsteel, and
L Levy
June 1971,
Leprosy review,
J H Peters, and
G R Gordon, and
J F Murray, and
A H Fieldsteel, and
L Levy
December 2000,
Leprosy review,
J H Peters, and
G R Gordon, and
J F Murray, and
A H Fieldsteel, and
L Levy
June 1992,
International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association,
J H Peters, and
G R Gordon, and
J F Murray, and
A H Fieldsteel, and
L Levy
October 1970,
Leprosy review,
J H Peters, and
G R Gordon, and
J F Murray, and
A H Fieldsteel, and
L Levy
January 1977,
Annales de la Societe belge de medecine tropicale,
J H Peters, and
G R Gordon, and
J F Murray, and
A H Fieldsteel, and
L Levy
January 1969,
International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association,
J H Peters, and
G R Gordon, and
J F Murray, and
A H Fieldsteel, and
L Levy
June 1988,
International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association,
J H Peters, and
G R Gordon, and
J F Murray, and
A H Fieldsteel, and
L Levy
June 2000,
Antimicrobial agents and chemotherapy,
J H Peters, and
G R Gordon, and
J F Murray, and
A H Fieldsteel, and
L Levy
April 1976,
Antimicrobial agents and chemotherapy,
J H Peters, and
G R Gordon, and
J F Murray, and
A H Fieldsteel, and
L Levy
April 2020,
Scientific reports,
