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The steady-state level of histone mRNAs fluctuates coordinately with chromosomal DNA synthesis during the cell cycle. Such an S phase-specific expression pattern results from transcriptional activation of histone genes coupled with the onset of replication and from transcriptional repression of the genes as well as specific destabilization of histone mRNAs around the end of the S phase. Proliferation-coupled and S phase-specific expression of histone genes is primarily achieved by the activities of the proximal promoter regions, where several conserved cis-acting elements have been identified. Among them, three kinds of Oct-containing composite elements (OCEs) play a pivotal role in S phase-specific transcriptional activation. Other ones, such as Nona, solo-Oct, and CCGTC motifs, appear to modulate the functions of OCEs to enhance or repress the transcriptional level, possibly depending on the state of the cells. Here, we review the growing evidence concerning the regulatory mechanisms by which plant histone genes are expressed S phase-specifically in proliferating cells.
T Meshi, and
K I Taoka, and
M Iwabuchi
March 1991,
Biochimica et biophysica acta,
T Meshi, and
K I Taoka, and
M Iwabuchi
May 1986,
Cell,
T Meshi, and
K I Taoka, and
M Iwabuchi
July 1998,
Nucleic acids research,
T Meshi, and
K I Taoka, and
M Iwabuchi
December 1984,
Molecular and cellular biology,
T Meshi, and
K I Taoka, and
M Iwabuchi
January 2002,
RNA (New York, N.Y.),
T Meshi, and
K I Taoka, and
M Iwabuchi
July 1989,
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme,
T Meshi, and
K I Taoka, and
M Iwabuchi
April 1989,
Current opinion in cell biology,
T Meshi, and
K I Taoka, and
M Iwabuchi
September 1978,
Experimental cell research,
T Meshi, and
K I Taoka, and
M Iwabuchi
January 1971,
In vitro,
T Meshi, and
K I Taoka, and
M Iwabuchi
January 1981,
International review of cytology,
