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Undernutrition has well-established effects on female reproduction. Here we describe the effects of food restriction on aspects of the hypothalamic-pituitary-gonadal (HPG) axis in the female musk shrew. We determined that acute re-feeding reverses deficits brought on by food restriction. Two days of food restriction led to an increase in proGnRH immunoreactive cells in the preoptic area relative to ad libitum-fed controls (AL). This increase was reversed by 90 min of ad libitum feeding in the re-fed females (RF). In addition, food-restricted (FR) females had significantly greater GnRH content in the median eminence than either the AL or RF females. After GnRH was administered, the majority of females in all food conditions ovulated, yet the FR females had significantly fewer corpora lutea than either the AL or RF animals. These data show that food restriction impairs HPG axis function in female musk shrews, and that some of these impairments can be rapidly reversed by acute re-feeding.
J L Temple, and
E F Rissman
January 2013,
Current medicinal chemistry,
J L Temple, and
E F Rissman
June 1998,
The Psychiatric clinics of North America,
J L Temple, and
E F Rissman
December 1984,
Danish medical bulletin,
J L Temple, and
E F Rissman
February 2013,
Age (Dordrecht, Netherlands),
J L Temple, and
E F Rissman
August 1975,
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J L Temple, and
E F Rissman
April 1992,
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J L Temple, and
E F Rissman
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J L Temple, and
E F Rissman
February 1985,
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J L Temple, and
E F Rissman
August 1988,
Acta psychiatrica Scandinavica,
J L Temple, and
E F Rissman
April 1991,
Molecular and cellular endocrinology,
