Neurocardiogenic syncope is a common disorder affecting various individuals of different ages with a wide variety of circumstances and comorbid conditions. Although a large amount of data is available regarding evaluation and treatment options, there is still sufficient latitude for the physician to exercise clinical judgment. We summarize current opinions on treatment here and also add some of our own bias regarding how to manage such patients. The vast majority of patients can be assessed by a reduction of symptomatic episodes with therapy. In all patients, careful follow-up should be made after initiating therapy. Not all patients will obtain complete resolution of symptoms. If episodes of complete syncope are reduced to infrequent dizzy spells, however, this may be satisfactory. In other patients, abrupt syncope may be converted to spells with a sufficient prodromal warning for the patient to take evasive action.