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PAcM-AN: poly (N-acryloylmorpholine)-conjugated antisense oligonucleotides. 2000
G M Bonora, and
A M De Franco, and
R Rossin, and
F M Veronese, and
P Ferruti, and
O Plyasunova, and
P E Vorobjev, and
D V Pyshnyi, and
N I Komarova, and
V F Zarytova
Dept. of Chemical Sciences, University of Trieste, Italy.
A new amphiphilic, high-molecular weight poly (N-acryloylmorpholine) (PAcM) polymer has been used to be linked to oligonucleotide chains through a liquid-phase stepwise synthesis. This new conjugate has been investigated for its melting property, nuclease stability and capacity to elicit RNase H activity. Its antisense activity against an HIV-1 target has been also evaluated.
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