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Continuous intravenous infusion of low doses of insulin has been successfully used since 1972 in the treatment of "diabetic coma". The achieved levels of plasma insulin satisfy the transport of glucose and the inhibition of lipolysis. We are to report upon 8 children (mean age: 8.5 years), 6 with diabetic ketoacidosis and 2 with hyperosmolar diabetic coma. Blood sugar levels of 300 mg/dl or less were reached after averagely 8 hours of therapy and an average consumption of 0.8 U insulin/kg. Sodium and potassium levels, osmolality and acid base parameters for the first 24 hours are described. Low-dose continuous intravenous insulin infusion was effective, simple and safe in all cases. The presently recommended dosage of 0.1 insulin/kg x hour is to be used flexibly (range: 0.05--0.2 U/kg x hour). The administration of bicarbonate should be cautiously used for patients with severe acidosis. Infusion of hypotonic solutions as part of the treatment of the hyperosmolar diabetic coma can be dangerous. A new therapeutic regime based on our results is proposed.
M Frank, and
H Hörnchen, and
R Joosten
September 1979,
Clinical pediatrics,
M Frank, and
H Hörnchen, and
R Joosten
March 1979,
Lijecnicki vjesnik,
M Frank, and
H Hörnchen, and
R Joosten
October 1978,
Revista brasileira de pesquisas medicas e biologicas,
M Frank, and
H Hörnchen, and
R Joosten
August 1978,
New York state journal of medicine,
M Frank, and
H Hörnchen, and
R Joosten
February 1980,
Lijecnicki vjesnik,
M Frank, and
H Hörnchen, and
R Joosten
November 1980,
Deutsche medizinische Wochenschrift (1946),
M Frank, and
H Hörnchen, and
R Joosten
June 1978,
La Nouvelle presse medicale,
M Frank, and
H Hörnchen, and
R Joosten
April 1993,
Journal of the American Veterinary Medical Association,
M Frank, and
H Hörnchen, and
R Joosten
December 1973,
Ugeskrift for laeger,
M Frank, and
H Hörnchen, and
R Joosten
November 1975,
Medical times,
