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The present study was carried out to investigate the effects of prolonged administration of C. parvum alone and in combination with cyclophosphamide for the treatment of established, measurable C3H tumors. The continued weekly administration of C. parvum by itself provided a limited but significant inhibitory effect on tumor growth and significantly prolonged survival. Intraperitoneal and intravenous administration was found to be more effective than the subcutaneous route. When C. parvum was administered asynchronously in combination with cyclophosphamide at weekly intervals a tumor growth inhibitory effect was achieved which was greater than that resulting from either agent along. Such an effect was consistently obtained and was seemingly independent of the sequence of drug administration. When cyclophosphamide preceded the initial C. parvum administration, arrest in the rate of tumor growth occurred, resulting in infinite tumor doubling time for the duration of observation (greater than 90 days). The combination of C. parvum and cyclophosphamide produced a more effective inhibition of tumor growth than did BCG and cyclophosphamide similarly employed. The importance of these findings relative to clinical application is considered. While the significance and genesis of the marked desmoplastic reaction characterizing tumors from animals treated with C. parvum and cyclophosphamide is at present speculative, consideration is given to the possibility that this could signify a host response against tumor growth.
B Fisher, and
N Wolmark, and
E Saffer, and
E R Fisher
October 1977,
Infection and immunity,
B Fisher, and
N Wolmark, and
E Saffer, and
E R Fisher
June 1981,
Gan,
B Fisher, and
N Wolmark, and
E Saffer, and
E R Fisher
November 1979,
Scandinavian journal of haematology,
B Fisher, and
N Wolmark, and
E Saffer, and
E R Fisher
June 1966,
British journal of cancer,
B Fisher, and
N Wolmark, and
E Saffer, and
E R Fisher
January 1978,
International journal of radiation oncology, biology, physics,
B Fisher, and
N Wolmark, and
E Saffer, and
E R Fisher
December 1977,
European journal of cancer,
B Fisher, and
N Wolmark, and
E Saffer, and
E R Fisher
March 1973,
Comptes rendus hebdomadaires des seances de l'Academie des sciences. Serie D: Sciences naturelles,
B Fisher, and
N Wolmark, and
E Saffer, and
E R Fisher
April 1979,
Journal of the National Cancer Institute,
B Fisher, and
N Wolmark, and
E Saffer, and
E R Fisher
November 1966,
Nature,
B Fisher, and
N Wolmark, and
E Saffer, and
E R Fisher
November 1983,
Neurologia medico-chirurgica,
