BIOMAT Database Logo BIOMAT Database Logo

Diabetes and tumor formation in transgenic mice expressing Reg I. 2000

T Yamaoka, and K Yoshino, and T Yamada, and C Idehara, and M O Hoque, and M Moritani, and K Yoshimoto, and J Hata, and M Itakura
Division of Genetic Information, Institute for Genome Research, University of Tokushima, Japan. yamoaka@genome.tokushima-u.ac.jp

To examine the effect of overexpressed regenerating gene (Reg) I on pancreatic beta-cells, we generated transgenic mice expressing Reg I in islets (Reg-Tg mice). Three lines of Reg-Tg mice were established. In line-1 Reg-Tg mice, the expression level of Reg I mRNA in islets was 7 times higher than those in lines 2 and 3 of Reg-Tg mice, and line 1 mice developed diabetes by apoptosis of beta-cells, as well as various malignant tumors. In addition to the decrease in beta-cells, compensatory islet regeneration and proliferation of ductal epithelial cells were observed in line-1 Reg-Tg mice. Because Reg I protein was secreted primarily into pancreatic ducts from acinar cells, it may primarily stimulate the proliferation of ductal epithelial cells, and not beta-cells, and their differentiation into islets. Moreover, the tumor-promoting activity of Reg I protein should be considered for its possible clinical applications.

UI MeSH Term Description Entries
D007328 Insulin A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1). Iletin,Insulin A Chain,Insulin B Chain,Insulin, Regular,Novolin,Sodium Insulin,Soluble Insulin,Chain, Insulin B,Insulin, Sodium,Insulin, Soluble,Regular Insulin
D007515 Islets of Langerhans Irregular microscopic structures consisting of cords of endocrine cells that are scattered throughout the PANCREAS among the exocrine acini. Each islet is surrounded by connective tissue fibers and penetrated by a network of capillaries. There are four major cell types. The most abundant beta cells (50-80%) secrete INSULIN. Alpha cells (5-20%) secrete GLUCAGON. PP cells (10-35%) secrete PANCREATIC POLYPEPTIDE. Delta cells (~5%) secrete SOMATOSTATIN. Islands of Langerhans,Islet Cells,Nesidioblasts,Pancreas, Endocrine,Pancreatic Islets,Cell, Islet,Cells, Islet,Endocrine Pancreas,Islet Cell,Islet, Pancreatic,Islets, Pancreatic,Langerhans Islands,Langerhans Islets,Nesidioblast,Pancreatic Islet
D008810 Mice, Inbred C57BL One of the first INBRED MOUSE STRAINS to be sequenced. This strain is commonly used as genetic background for transgenic mouse models. Refractory to many tumors, this strain is also preferred model for studying role of genetic variations in development of diseases. Mice, C57BL,Mouse, C57BL,Mouse, Inbred C57BL,C57BL Mice,C57BL Mice, Inbred,C57BL Mouse,C57BL Mouse, Inbred,Inbred C57BL Mice,Inbred C57BL Mouse
D008811 Mice, Inbred DBA An inbred strain of mouse. Specific substrains are used in a variety of areas of BIOMEDICAL RESEARCH such as DBA/1J, which is used as a model for RHEUMATOID ARTHRITIS. Mice, DBA,Mouse, DBA,Mouse, Inbred DBA,DBA Mice,DBA Mice, Inbred,DBA Mouse,DBA Mouse, Inbred,Inbred DBA Mice,Inbred DBA Mouse
D008822 Mice, Transgenic Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN. Transgenic Mice,Founder Mice, Transgenic,Mouse, Founder, Transgenic,Mouse, Transgenic,Mice, Transgenic Founder,Transgenic Founder Mice,Transgenic Mouse
D009374 Neoplasms, Experimental Experimentally induced new abnormal growth of TISSUES in animals to provide models for studying human neoplasms. Experimental Neoplasms,Experimental Neoplasm,Neoplasm, Experimental
D010641 Phenotype The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment. Phenotypes
D012038 Regeneration The physiological renewal, repair, or replacement of tissue. Endogenous Regeneration,Regeneration, Endogenous,Regenerations
D003921 Diabetes Mellitus, Experimental Diabetes mellitus induced experimentally by administration of various diabetogenic agents or by PANCREATECTOMY. Alloxan Diabetes,Streptozocin Diabetes,Streptozotocin Diabetes,Experimental Diabetes Mellitus,Diabete, Streptozocin,Diabetes, Alloxan,Diabetes, Streptozocin,Diabetes, Streptozotocin,Streptozocin Diabete
D005260 Female Females

Related Publications

T Yamaoka, and K Yoshino, and T Yamada, and C Idehara, and M O Hoque, and M Moritani, and K Yoshimoto, and J Hata, and M Itakura
Obesity and diabetes in transgenic mice expressing proSAAS.
March 2004, The Journal of endocrinology,
T Yamaoka, and K Yoshino, and T Yamada, and C Idehara, and M O Hoque, and M Moritani, and K Yoshimoto, and J Hata, and M Itakura
Complete prevention of diabetes in transgenic NOD mice expressing I-E molecules.
January 1992, Immunology letters,
T Yamaoka, and K Yoshino, and T Yamada, and C Idehara, and M O Hoque, and M Moritani, and K Yoshimoto, and J Hata, and M Itakura
Resistance to cyclophosphamide-induced diabetes in transgenic NOD mice expressing I-Ak.
January 1994, Autoimmunity,
T Yamaoka, and K Yoshino, and T Yamada, and C Idehara, and M O Hoque, and M Moritani, and K Yoshimoto, and J Hata, and M Itakura
Tau filament formation in transgenic mice expressing P301L tau.
January 2001, The Journal of biological chemistry,
T Yamaoka, and K Yoshino, and T Yamada, and C Idehara, and M O Hoque, and M Moritani, and K Yoshimoto, and J Hata, and M Itakura
Tolerance and diabetes in transgenic mice over-expressing class I histocompatibility molecules in pancreatic beta cells.
April 1990, Journal of autoimmunity,
T Yamaoka, and K Yoshino, and T Yamada, and C Idehara, and M O Hoque, and M Moritani, and K Yoshimoto, and J Hata, and M Itakura
Oligodendroglial tau filament formation in transgenic mice expressing G272V tau.
June 2001, The European journal of neuroscience,
T Yamaoka, and K Yoshino, and T Yamada, and C Idehara, and M O Hoque, and M Moritani, and K Yoshimoto, and J Hata, and M Itakura
Diabetes and pancreatic tumours in transgenic mice expressing Pa x 6.
March 2000, Diabetologia,
T Yamaoka, and K Yoshino, and T Yamada, and C Idehara, and M O Hoque, and M Moritani, and K Yoshimoto, and J Hata, and M Itakura
Spontaneous diabetes mellitus in transgenic mice expressing human islet amyloid polypeptide.
July 1996, Proceedings of the National Academy of Sciences of the United States of America,
T Yamaoka, and K Yoshino, and T Yamada, and C Idehara, and M O Hoque, and M Moritani, and K Yoshimoto, and J Hata, and M Itakura
Mammary tumor induction in transgenic mice expressing an RNA-binding protein.
January 2004, Cancer research,
T Yamaoka, and K Yoshino, and T Yamada, and C Idehara, and M O Hoque, and M Moritani, and K Yoshimoto, and J Hata, and M Itakura
Formation of filamentous tau aggregations in transgenic mice expressing V337M human tau.
December 2001, Neurobiology of disease,
Copied contents to your clipboard!