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Glomerular basement membrane (GBM) thickness was measured in diabetic rats prior to and following islet transplantation. Over the course of the experiment (from 7 to 13 months of diabetes) GBM thickness in diabetic animals exceeded that of littermate controls. After 7 months of diabetes a group of animals received successful intraportal transplants of neonatal pancreatic tissue. GBM thickness at 2 and 6 months following islet transplantation matched the thickness in nontransplanted diabetic rats and exceeded that in control animals. Failure to reverse GBM thickening in diabetic rats following islet transplantation may be due to very slow rates of GBM tunover in the rat. Previous work has demonstrated normalization of urinary albumin excretion after islet transplantation, suggesting that GBM thickening, per se, is not a significant factor causing albuminuria in rats with longstanding diabetes.
M W Steffes, and
D M Brown, and
J M Basgen, and
A J Matas, and
S M Mauer
August 1984,
Laboratory investigation; a journal of technical methods and pathology,
M W Steffes, and
D M Brown, and
J M Basgen, and
A J Matas, and
S M Mauer
February 1979,
Diabetes,
M W Steffes, and
D M Brown, and
J M Basgen, and
A J Matas, and
S M Mauer
January 2001,
International journal of experimental diabetes research,
M W Steffes, and
D M Brown, and
J M Basgen, and
A J Matas, and
S M Mauer
January 2016,
Ultrastructural pathology,
M W Steffes, and
D M Brown, and
J M Basgen, and
A J Matas, and
S M Mauer
March 1988,
Diabetologia,
M W Steffes, and
D M Brown, and
J M Basgen, and
A J Matas, and
S M Mauer
October 1976,
The Journal of clinical investigation,
M W Steffes, and
D M Brown, and
J M Basgen, and
A J Matas, and
S M Mauer
May 1989,
Diabetologia,
M W Steffes, and
D M Brown, and
J M Basgen, and
A J Matas, and
S M Mauer
April 1988,
Pediatric nephrology (Berlin, Germany),
M W Steffes, and
D M Brown, and
J M Basgen, and
A J Matas, and
S M Mauer
September 2002,
Kidney international,
M W Steffes, and
D M Brown, and
J M Basgen, and
A J Matas, and
S M Mauer
August 1972,
The Australian journal of experimental biology and medical science,
