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Twenty-five patients with chest pain were studied by left ventriculography and coronary arteriography. Myocardial metabolic studies were done during control state, pacing tachycardia, isometric hand grip at 30 per cent of maximum force, and combined hand grip plus pacing tachycardia. Nine patients had myocardial lactate abnormality (group 1) as evidenced by myocardial lactate production or decreased extraction (less than 10%). Though tension time index and triple product (left ventricular ejection time times HR times systolic pressure) as determinants of myocardial oxygen consumption were highest during combined hand grip plus pacing tachycardia, myocardial lactate abnormalities were most frequent during pacing tachycardia. The present study indicates that isometric hand grip even if performed during pacing tachycardia is not a sensitive test for detection of myocardial lactate abnormalities. The rising level of arterial lactate during isometric hand grip is the most likely mechanism of positive myocardial arteriovenous lactate difference.
F K Nakhjavan, and
G Natarajan, and
A M Smith, and
M Dratch, and
H Goldberg
February 1983,
Scandinavian journal of clinical and laboratory investigation,
F K Nakhjavan, and
G Natarajan, and
A M Smith, and
M Dratch, and
H Goldberg
January 1973,
Investigative radiology,
F K Nakhjavan, and
G Natarajan, and
A M Smith, and
M Dratch, and
H Goldberg
January 1982,
Arquivos brasileiros de cardiologia,
F K Nakhjavan, and
G Natarajan, and
A M Smith, and
M Dratch, and
H Goldberg
May 1973,
Clinical science,
F K Nakhjavan, and
G Natarajan, and
A M Smith, and
M Dratch, and
H Goldberg
June 1981,
Circulation research,
F K Nakhjavan, and
G Natarajan, and
A M Smith, and
M Dratch, and
H Goldberg
November 1975,
Japanese circulation journal,
F K Nakhjavan, and
G Natarajan, and
A M Smith, and
M Dratch, and
H Goldberg
May 2009,
The Journal of physiology,
F K Nakhjavan, and
G Natarajan, and
A M Smith, and
M Dratch, and
H Goldberg
January 2001,
Journal of hand therapy : official journal of the American Society of Hand Therapists,
F K Nakhjavan, and
G Natarajan, and
A M Smith, and
M Dratch, and
H Goldberg
August 1996,
Clinical autonomic research : official journal of the Clinical Autonomic Research Society,
F K Nakhjavan, and
G Natarajan, and
A M Smith, and
M Dratch, and
H Goldberg
November 2012,
Journal of strength and conditioning research,
