BIOMAT Database Logo BIOMAT Database Logo

Expression of CD40 in vascular smooth muscle cells and macrophages is associated with early development of human atherosclerotic lesions. 2001

D Bruemmer, and U Riggers, and J Holzmeister, and M Grill, and F Lippek, and U Settmacher, and V Regitz-Zagrosek, and E Fleck, and K Graf
Department of Medicine/Cardiology, Virchow Klinikum Humboldt Universität Berlin, Germany.

CD40-CD154-mediated signaling has recently been described as playing a role in cellular functions involved in atherosclerotic processes. CD40 is expressed in macrophages, lymphocytes, endothelial cells, and vascular smooth muscle cells. However, cross-sectional studies investigating the expression of CD40 in atherosclerotic lesions are lacking. In the present study the expression of CD40 was studied in atherosclerotic lesions from 43 patients classified according to the World Health Organization criteria. Serial immunohistologic stainings of human iliac arteries from 43 patients were performed using monoclonal antibodies. Lesions were classified according to World Health Organization criteria, and CD40 expression was analyzed with regard to cell morphology and cellular markers by 2 independent observers. Human atherosclerotic lesions revealed a significant increase in intimal thickness, number of inflammatory infiltrates, and CD40-positive macrophages and vascular smooth muscle cells with progression of the lesions. This increase was most prominent from stage 0 to stage I. A significant correlation between intimal thickness and CD40-positive macrophages (r = 0.75, p <0.0005) and CD40-positive vascular smooth muscle cells (r = 0.81, p <0.0005) was observed. Ligation of the cellular CD40 receptor contributes to inflammatory cellular events in human vascular smooth muscle cells. These data suggest a direct association of CD40 expression in atherosclerotic lesions with early plaque development.

UI MeSH Term Description Entries
D007083 Iliac Artery Either of two large arteries originating from the abdominal aorta; they supply blood to the pelvis, abdominal wall and legs. Deep Circumflex Iliac Artery,Arteries, Iliac,Artery, Iliac,Iliac Arteries
D007150 Immunohistochemistry Histochemical localization of immunoreactive substances using labeled antibodies as reagents. Immunocytochemistry,Immunogold Techniques,Immunogold-Silver Techniques,Immunohistocytochemistry,Immunolabeling Techniques,Immunogold Technics,Immunogold-Silver Technics,Immunolabeling Technics,Immunogold Silver Technics,Immunogold Silver Techniques,Immunogold Technic,Immunogold Technique,Immunogold-Silver Technic,Immunogold-Silver Technique,Immunolabeling Technic,Immunolabeling Technique,Technic, Immunogold,Technic, Immunogold-Silver,Technic, Immunolabeling,Technics, Immunogold,Technics, Immunogold-Silver,Technics, Immunolabeling,Technique, Immunogold,Technique, Immunogold-Silver,Technique, Immunolabeling,Techniques, Immunogold,Techniques, Immunogold-Silver,Techniques, Immunolabeling
D008264 Macrophages The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.) Bone Marrow-Derived Macrophages,Monocyte-Derived Macrophages,Macrophage,Macrophages, Monocyte-Derived,Bone Marrow Derived Macrophages,Bone Marrow-Derived Macrophage,Macrophage, Bone Marrow-Derived,Macrophage, Monocyte-Derived,Macrophages, Bone Marrow-Derived,Macrophages, Monocyte Derived,Monocyte Derived Macrophages,Monocyte-Derived Macrophage
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D009131 Muscle, Smooth, Vascular The nonstriated involuntary muscle tissue of blood vessels. Vascular Smooth Muscle,Muscle, Vascular Smooth,Muscles, Vascular Smooth,Smooth Muscle, Vascular,Smooth Muscles, Vascular,Vascular Smooth Muscles
D003430 Cross-Sectional Studies Studies in which the presence or absence of disease or other health-related variables are determined in each member of the study population or in a representative sample at one particular time. This contrasts with LONGITUDINAL STUDIES which are followed over a period of time. Disease Frequency Surveys,Prevalence Studies,Analysis, Cross-Sectional,Cross Sectional Analysis,Cross-Sectional Survey,Surveys, Disease Frequency,Analyses, Cross Sectional,Analyses, Cross-Sectional,Analysis, Cross Sectional,Cross Sectional Analyses,Cross Sectional Studies,Cross Sectional Survey,Cross-Sectional Analyses,Cross-Sectional Analysis,Cross-Sectional Study,Cross-Sectional Surveys,Disease Frequency Survey,Prevalence Study,Studies, Cross-Sectional,Studies, Prevalence,Study, Cross-Sectional,Study, Prevalence,Survey, Cross-Sectional,Survey, Disease Frequency,Surveys, Cross-Sectional
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000368 Aged A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available. Elderly

Related Publications

D Bruemmer, and U Riggers, and J Holzmeister, and M Grill, and F Lippek, and U Settmacher, and V Regitz-Zagrosek, and E Fleck, and K Graf
Do vascular smooth muscle cells differentiate to macrophages in atherosclerotic lesions?
September 2014, Circulation research,
D Bruemmer, and U Riggers, and J Holzmeister, and M Grill, and F Lippek, and U Settmacher, and V Regitz-Zagrosek, and E Fleck, and K Graf
Functional CD40 ligand is expressed on human vascular endothelial cells, smooth muscle cells, and macrophages: implications for CD40-CD40 ligand signaling in atherosclerosis.
March 1997, Proceedings of the National Academy of Sciences of the United States of America,
D Bruemmer, and U Riggers, and J Holzmeister, and M Grill, and F Lippek, and U Settmacher, and V Regitz-Zagrosek, and E Fleck, and K Graf
Decay-accelerating factor is expressed on vascular smooth muscle cells in human atherosclerotic lesions.
August 1989, The Journal of clinical investigation,
D Bruemmer, and U Riggers, and J Holzmeister, and M Grill, and F Lippek, and U Settmacher, and V Regitz-Zagrosek, and E Fleck, and K Graf
Autophagy of vascular smooth muscle cells in atherosclerotic lesions.
January 2007, Autophagy,
D Bruemmer, and U Riggers, and J Holzmeister, and M Grill, and F Lippek, and U Settmacher, and V Regitz-Zagrosek, and E Fleck, and K Graf
CD40 ligation induces tissue factor expression in human vascular smooth muscle cells.
January 2000, The American journal of pathology,
D Bruemmer, and U Riggers, and J Holzmeister, and M Grill, and F Lippek, and U Settmacher, and V Regitz-Zagrosek, and E Fleck, and K Graf
Macrophages and smooth muscle cells express lipoprotein lipase in human and rabbit atherosclerotic lesions.
November 1991, Proceedings of the National Academy of Sciences of the United States of America,
D Bruemmer, and U Riggers, and J Holzmeister, and M Grill, and F Lippek, and U Settmacher, and V Regitz-Zagrosek, and E Fleck, and K Graf
Crosstalk between macrophages and smooth muscle cells in atherosclerotic vascular diseases.
August 2012, Vascular pharmacology,
D Bruemmer, and U Riggers, and J Holzmeister, and M Grill, and F Lippek, and U Settmacher, and V Regitz-Zagrosek, and E Fleck, and K Graf
Angiotensin II modulates CD40 expression in vascular smooth muscle cells.
March 2009, Clinical science (London, England : 1979),
D Bruemmer, and U Riggers, and J Holzmeister, and M Grill, and F Lippek, and U Settmacher, and V Regitz-Zagrosek, and E Fleck, and K Graf
Expression of inducible nitric oxide synthase in macrophages and smooth muscle cells in various types of human atherosclerotic lesions.
June 1999, Virchows Archiv : an international journal of pathology,
D Bruemmer, and U Riggers, and J Holzmeister, and M Grill, and F Lippek, and U Settmacher, and V Regitz-Zagrosek, and E Fleck, and K Graf
Hypernuclear acetylation in atherosclerotic lesions and activated vascular smooth muscle cells.
December 1999, Biochemical and biophysical research communications,
Copied contents to your clipboard!