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In chronic virus hepatitis B the causative virus replicates for a long time as manifested by HBsAg persistence. Examinations of 92 sick children revealed changes in cellular and humoral immunity indices. The content of T-lymphocytes (determined according to Bach et al.) was reduced to 31.5 +/- 1.4% in the exacerbation stage (the normal content 50.8 +/- 1.3%), the percentage of O-cells increased, while the number of B-cells according to Mendes et al. did not change significantly. The inhibition of adhesion of A-cells (Halliday et al.--A. F. Blyuger) and "immune" plaque formation (according to A. F. Blyuger) in the presence of HBsAg were also increased maximally in the exacerbation stage. HBs-antigenemia was found to occur most frequently in the exacerbation stage. The content of immunoglobulin G was reduced. An increase in the number of tissue lymphocytes and their blast forms (in the "skin window" sample by Rebuck) was demonstrated. The authors assume that the long-term persistence of HBs-Ag and, consequently, the maintenance of the pathologic process activity are due to a defficiency of cellular immunity factors. The prospects of enhancing cellular immunity in virus hepatitis B in children are discussed.
I V Gol'zand, and
V O Volkov, and
L M Shibova-Borskaia, and
L G Nezhentseva, and
G S Blagoslovenskiĭ
February 1987,
Polski tygodnik lekarski (Warsaw, Poland : 1960),
I V Gol'zand, and
V O Volkov, and
L M Shibova-Borskaia, and
L G Nezhentseva, and
G S Blagoslovenskiĭ
May 1976,
American journal of clinical pathology,
I V Gol'zand, and
V O Volkov, and
L M Shibova-Borskaia, and
L G Nezhentseva, and
G S Blagoslovenskiĭ
June 1981,
Polski tygodnik lekarski (Warsaw, Poland : 1960),
I V Gol'zand, and
V O Volkov, and
L M Shibova-Borskaia, and
L G Nezhentseva, and
G S Blagoslovenskiĭ
September 1980,
Voprosy okhrany materinstva i detstva,
I V Gol'zand, and
V O Volkov, and
L M Shibova-Borskaia, and
L G Nezhentseva, and
G S Blagoslovenskiĭ
March 1975,
British medical journal,
I V Gol'zand, and
V O Volkov, and
L M Shibova-Borskaia, and
L G Nezhentseva, and
G S Blagoslovenskiĭ
December 1983,
Zhurnal mikrobiologii, epidemiologii i immunobiologii,
I V Gol'zand, and
V O Volkov, and
L M Shibova-Borskaia, and
L G Nezhentseva, and
G S Blagoslovenskiĭ
February 1982,
Zhurnal mikrobiologii, epidemiologii i immunobiologii,
I V Gol'zand, and
V O Volkov, and
L M Shibova-Borskaia, and
L G Nezhentseva, and
G S Blagoslovenskiĭ
September 1978,
[Hokkaido igaku zasshi] The Hokkaido journal of medical science,
I V Gol'zand, and
V O Volkov, and
L M Shibova-Borskaia, and
L G Nezhentseva, and
G S Blagoslovenskiĭ
September 1983,
Clinical nephrology,
I V Gol'zand, and
V O Volkov, and
L M Shibova-Borskaia, and
L G Nezhentseva, and
G S Blagoslovenskiĭ
January 1981,
Sbornik vedeckych praci Lekarske fakulty Karlovy univerzity v Hradci Kralove. Supplementum,
