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A hemoglobin variant with the slightly fast mobility associated with K hemoglobins was found, together with hemoglobin S, in an apparently healthy 3-year-old Negro girl from Washington, D.C. Her father had the same variant, along with hemoglobin A, and her mother had hemoglobins A plus S. Respective proportions of hemoglobins K and S in the propositus were 66-34. The K variant now has been found to have the structural change Gln yields Glu at position beta-131 (beta-H9); therefore it apparently is identical to hemoglobin Camden reported in trait form in a Negro subject by YATES, BELLINGHAM and HUEHNS (Nature 243: 467-468, 1973).
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