BIOMAT Database Logo BIOMAT Database Logo

Fatal pulmonary infection due to multidrug-resistant Mycobacterium abscessus in a patient with cystic fibrosis. 2001

M Sanguinetti, and F Ardito, and E Fiscarelli, and M La Sorda, and P D'Argenio, and G Ricciotti, and G Fadda
Istituto di Microbiologia, Università Cattolica del S. Cuore, Ospedale Pediatrico Bambino Gesù, Rome, Italy. msanguinetti@rm.unicatt.it

We report a case of fatal pulmonary infection caused by Mycobacterium abscessus in a young patient with cystic fibrosis, who underwent bipulmonary transplantation after a 1-year history of severe lung disease. Fifteen days after surgery he developed septic fever with progressive deterioration in lung function. M. abscessus, initially isolated from a pleural fluid specimen, was then recovered from repeated blood samples, suggesting a disseminated nature of the mycobacterial disease. Drug susceptibility testing assay, performed on two sequential isolates of the microorganism, showed a pattern of multidrug resistance. Despite aggressive therapy with several antimycobacterial drugs, including clarithromycin, the infection persisted, and the patient died.

UI MeSH Term Description Entries
D008171 Lung Diseases Pathological processes involving any part of the LUNG. Pulmonary Diseases,Disease, Pulmonary,Diseases, Pulmonary,Pulmonary Disease,Disease, Lung,Diseases, Lung,Lung Disease
D008297 Male Males
D008826 Microbial Sensitivity Tests Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses). Bacterial Sensitivity Tests,Drug Sensitivity Assay, Microbial,Minimum Inhibitory Concentration,Antibacterial Susceptibility Breakpoint Determination,Antibiogram,Antimicrobial Susceptibility Breakpoint Determination,Bacterial Sensitivity Test,Breakpoint Determination, Antibacterial Susceptibility,Breakpoint Determination, Antimicrobial Susceptibility,Fungal Drug Sensitivity Tests,Fungus Drug Sensitivity Tests,Sensitivity Test, Bacterial,Sensitivity Tests, Bacterial,Test, Bacterial Sensitivity,Tests, Bacterial Sensitivity,Viral Drug Sensitivity Tests,Virus Drug Sensitivity Tests,Antibiograms,Concentration, Minimum Inhibitory,Concentrations, Minimum Inhibitory,Inhibitory Concentration, Minimum,Inhibitory Concentrations, Minimum,Microbial Sensitivity Test,Minimum Inhibitory Concentrations,Sensitivity Test, Microbial,Sensitivity Tests, Microbial,Test, Microbial Sensitivity,Tests, Microbial Sensitivity
D009161 Mycobacterium A genus of gram-positive, aerobic bacteria. Most species are free-living in soil and water, but the major habitat for some is the diseased tissue of warm-blooded hosts. Mycobacteria
D009164 Mycobacterium Infections Infections with bacteria of the genus MYCOBACTERIUM. Infections, Mycobacterium,Infection, Mycobacterium,Mycobacterium Infection
D011183 Postoperative Complications Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery. Complication, Postoperative,Complications, Postoperative,Postoperative Complication
D003550 Cystic Fibrosis An autosomal recessive genetic disease of the EXOCRINE GLANDS. It is caused by mutations in the gene encoding the CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR expressed in several organs including the LUNG, the PANCREAS, the BILIARY SYSTEM, and the SWEAT GLANDS. Cystic fibrosis is characterized by epithelial secretory dysfunction associated with ductal obstruction resulting in AIRWAY OBSTRUCTION; chronic RESPIRATORY INFECTIONS; PANCREATIC INSUFFICIENCY; maldigestion; salt depletion; and HEAT PROSTRATION. Mucoviscidosis,Cystic Fibrosis of Pancreas,Fibrocystic Disease of Pancreas,Pancreatic Cystic Fibrosis,Pulmonary Cystic Fibrosis,Cystic Fibrosis, Pancreatic,Cystic Fibrosis, Pulmonary,Fibrosis, Cystic,Pancreas Fibrocystic Disease,Pancreas Fibrocystic Diseases
D004359 Drug Therapy, Combination Therapy with two or more separate preparations given for a combined effect. Combination Chemotherapy,Polychemotherapy,Chemotherapy, Combination,Combination Drug Therapy,Drug Polytherapy,Therapy, Combination Drug,Chemotherapies, Combination,Combination Chemotherapies,Combination Drug Therapies,Drug Polytherapies,Drug Therapies, Combination,Polychemotherapies,Polytherapies, Drug,Polytherapy, Drug,Therapies, Combination Drug
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults

Related Publications

M Sanguinetti, and F Ardito, and E Fiscarelli, and M La Sorda, and P D'Argenio, and G Ricciotti, and G Fadda
Multidrug-resistant Mycobacterium abscessus threatens patients with cystic fibrosis.
January 2017, The Lancet. Respiratory medicine,
M Sanguinetti, and F Ardito, and E Fiscarelli, and M La Sorda, and P D'Argenio, and G Ricciotti, and G Fadda
Pulmonary infection due to multidrug-resistant Mycobacterium szulgai in a patient with AIDS.
June 1994, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America,
M Sanguinetti, and F Ardito, and E Fiscarelli, and M La Sorda, and P D'Argenio, and G Ricciotti, and G Fadda
Mycobacterium abscessus infection in a cystic fibrosis patient: a difficult to treat infection.
February 2010, The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease,
M Sanguinetti, and F Ardito, and E Fiscarelli, and M La Sorda, and P D'Argenio, and G Ricciotti, and G Fadda
Fatal pulmonary Mycobacterium abscessus infection in a patient using etanercept.
January 2006, Hawaii medical journal,
M Sanguinetti, and F Ardito, and E Fiscarelli, and M La Sorda, and P D'Argenio, and G Ricciotti, and G Fadda
Fatal pulmonary infection with Mycobacterium fortuitum in cystic fibrosis.
July 1984, British journal of diseases of the chest,
M Sanguinetti, and F Ardito, and E Fiscarelli, and M La Sorda, and P D'Argenio, and G Ricciotti, and G Fadda
[Pulmonary Mycobacterium abscessus sensu lato infection in patients without cystic fibrosis].
March 2016, Revue des maladies respiratoires,
M Sanguinetti, and F Ardito, and E Fiscarelli, and M La Sorda, and P D'Argenio, and G Ricciotti, and G Fadda
Mycobacterium abscessus infection in cystic fibrosis. Colonization or infection?
February 2000, American journal of respiratory and critical care medicine,
M Sanguinetti, and F Ardito, and E Fiscarelli, and M La Sorda, and P D'Argenio, and G Ricciotti, and G Fadda
Fatal pulmonary infection due to multidrug-resistant Mycobacterium kansasii which developed in an immunocompetent young man.
April 1997, Internal medicine (Tokyo, Japan),
M Sanguinetti, and F Ardito, and E Fiscarelli, and M La Sorda, and P D'Argenio, and G Ricciotti, and G Fadda
Mycobacterium abscessus in cystic fibrosis.
April 2021, Science (New York, N.Y.),
M Sanguinetti, and F Ardito, and E Fiscarelli, and M La Sorda, and P D'Argenio, and G Ricciotti, and G Fadda
Pseudomonas cepacia--fatal pulmonary infection in a patient with cystic fibrosis.
September 1986, The Journal of infection,
Copied contents to your clipboard!