Mathematical model of a hybrid dispersed network-membrane-based controlled release system. 2001

S Farrell, and K K Sirkar
Department of Chemical Engineering, Chemistry and Environmental Science, New Jersey Institute of Technology, Newark, NJ 07102, USA.

A mathematical model with an exact solution is presented for the controlled release of a drug from a hybrid dispersed network-membrane based system. Both hollow fiber and flat membrane device geometries are considered. The reservoir is loaded with a drug dispersed in a liquid phase. This reservoir is bounded by a microporous membrane, the pores of which are filled with liquid immiscible with the reservoir phase liquid. The drug dissolves from the solid network into the reservoir liquid and migrates through the reservoir toward the microporous membrane. At the interface between the reservoir and the pore, the solute partitions between the reservoir and the pore liquid phases, before diffusing outward through the membrane pore. Experimental results are in close agreement with the release profiles predicted by the mathematical model. Parametric studies reveal the interaction between system parameters and the controlled release behavior. The presence of a dispersed drug phase in the reservoir results in the release of drug for an extended time. The release rate of the drug may be controlled by its rate of diffusion through the membrane pores or by its rate of dissolution into the reservoir liquid.

UI MeSH Term Description Entries
D008433 Mathematics The deductive study of shape, quantity, and dependence. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed) Mathematic
D008962 Models, Theoretical Theoretical representations that simulate the behavior or activity of systems, processes, or phenomena. They include the use of mathematical equations, computers, and other electronic equipment. Experimental Model,Experimental Models,Mathematical Model,Model, Experimental,Models (Theoretical),Models, Experimental,Models, Theoretic,Theoretical Study,Mathematical Models,Model (Theoretical),Model, Mathematical,Model, Theoretical,Models, Mathematical,Studies, Theoretical,Study, Theoretical,Theoretical Model,Theoretical Models,Theoretical Studies
D002626 Chemistry, Pharmaceutical Chemistry dealing with the composition and preparation of agents having PHARMACOLOGIC ACTIONS or diagnostic use. Medicinal Chemistry,Chemistry, Pharmaceutic,Pharmaceutic Chemistry,Pharmaceutical Chemistry,Chemistry, Medicinal
D012995 Solubility The ability of a substance to be dissolved, i.e. to form a solution with another substance. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed) Solubilities
D016503 Drug Delivery Systems Systems for the delivery of drugs to target sites of pharmacological actions. Technologies employed include those concerning drug preparation, route of administration, site targeting, metabolism, and toxicity. Drug Targeting,Delivery System, Drug,Delivery Systems, Drug,Drug Delivery System,Drug Targetings,System, Drug Delivery,Systems, Drug Delivery,Targeting, Drug,Targetings, Drug

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