Biomaterial Database

Effects of antibiotics on the in vitro rabbit corneal endothelium. 1975

W H Coles

The effects of ten antibiotics and two preservatives on the rabbit corneal endothelium were studied by in vitro perfusion. Dose-related effects on corneal thickness were seen with certain antibiotics. No correlation was found between structure, origin, or bacterial sensitivity of the antibiotics and their effect on corneal transplants. Five distinct morphological changes were observed: two were transient and only one was specific. Although clinical dose correlation was not intended, further investigation is needed on erythromycin, bacitracin, chloramphenicol, penicillin, oxacillin, and cephalothin.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D008712	Methicillin	One of the PENICILLINS which is resistant to PENICILLINASE but susceptible to a penicillin-binding protein. It is inactivated by gastric acid so administered by injection.	Penicillin, Dimethoxyphenyl,Methicillin Hydrate, Monosodium Salt,Methicillin Monohydrate, Monosodium Salt,Methicillin Sodium,Meticillin,Metin,Staphcillin,Dimethoxyphenyl Penicillin
D010068	Oxacillin	An antibiotic similar to FLUCLOXACILLIN used in resistant staphylococci infections.	Oxazocilline,Penicillin, Methylphenylisoxazolyl,Sodium Oxacillin,Oxacillin Sodium,Oxacillin, Monosodium Salt, Anhydrous,Oxacillin, Monosodium Salt, Monohydrate,Prostaphlin,Methylphenylisoxazolyl Penicillin,Oxacillin, Sodium,Sodium, Oxacillin
D010226	Parabens	Methyl, propyl, butyl, and ethyl esters of p-hydroxybenzoic acid. They have been approved by the FDA as antimicrobial agents for foods and pharmaceuticals. (From Hawley's Condensed Chemical Dictionary, 11th ed, p872)	4-Hydroxybenzoic Acids,Paraben,para-Hydroxybenzoic Acids,4 Hydroxybenzoic Acids,para Hydroxybenzoic Acids
D010400	Penicillin G	A penicillin derivative commonly used in the form of its sodium or potassium salts in the treatment of a variety of infections. It is effective against most gram-positive bacteria and against gram-negative cocci. It has also been used as an experimental convulsant because of its actions on GAMMA-AMINOBUTYRIC ACID mediated synaptic transmission.	Benzylpenicillin,Benpen,Benzylpenicillin Potassium,Coliriocilina,Crystapen,Or-pen,Parcillin,Pekamin,Pengesod,Penibiot,Penicilina G Llorente,Penicillin G Jenapharm,Penicillin G Potassium,Penicillin G Sodium,Penicillin Grünenthal,Penilevel,Peniroger,Pfizerpen,Sodiopen,Sodipen,Sodium Benzylpenicillin,Sodium Penicillin,Unicilina,Ursopen,Van-Pen-G
D010477	Perfusion	Treatment process involving the injection of fluid into an organ or tissue.	Perfusions
D011817	Rabbits	A burrowing plant-eating mammal with hind limbs that are longer than its fore limbs. It belongs to the family Leporidae of the order Lagomorpha, and in contrast to hares, possesses 22 instead of 24 pairs of chromosomes.	Belgian Hare,New Zealand Rabbit,New Zealand Rabbits,New Zealand White Rabbit,Rabbit,Rabbit, Domestic,Chinchilla Rabbits,NZW Rabbits,New Zealand White Rabbits,Oryctolagus cuniculus,Chinchilla Rabbit,Domestic Rabbit,Domestic Rabbits,Hare, Belgian,NZW Rabbit,Rabbit, Chinchilla,Rabbit, NZW,Rabbit, New Zealand,Rabbits, Chinchilla,Rabbits, Domestic,Rabbits, NZW,Rabbits, New Zealand,Zealand Rabbit, New,Zealand Rabbits, New,cuniculus, Oryctolagus
D002509	Cephaloridine	A cephalosporin antibiotic.	Cefaloridine,Cephalomycine,Cephaloridin,Ceporin
D002512	Cephalothin	A cephalosporin antibiotic.	Cefalotin,Sodium Cephalothin,Cefalotina Normon,Cefalotina Sodica Spaly,Ceftina,Cephalothin Monosodium Salt,Keflin,Seffin,Cephalothin, Sodium,Monosodium Salt, Cephalothin,Salt, Cephalothin Monosodium
D002701	Chloramphenicol	An antibiotic first isolated from cultures of Streptomyces venequelae in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. (From Martindale, The Extra Pharmacopoeia, 29th ed, p106)	Cloranfenicol,Kloramfenikol,Levomycetin,Amphenicol,Amphenicols,Chlornitromycin,Chlorocid,Chloromycetin,Detreomycin,Ophthochlor,Syntomycin