-transparent.png){kind=logo}
Partial deletion of the short arm of chromosome 4 (4p-) represents another (rare) cause of cleft lip and cleft palate. Further characteristic manifestations of the syndrome (also called Wolf or Wolf-Hirschhorn syndrome) are growth failure, microcephaly, prominent glabella, hypertelorism, beaked nose, poorly differentiated and low set ears, cardiac and renal malformation and hypospadias. Life expectancy is often shortened. The 4p- syndrome has many features in common with another deletion syndrome, the cri-du-chat syndrome, and also with the Smith-Lemli-Opitz syndrome. The latter is a hereditary condition with normal karyotype. The cri-du-chat syndrome is characterized by a peculiar high-pitched, mewing cry and can be differentiated from the Wolf syndrome by the different staining characteristics (banding) of chromosomes 4 and 5.
H Zellweger, and
J Bardach, and
J Bordwell, and
K Williams
October 1970,
Annals of human genetics,
H Zellweger, and
J Bardach, and
J Bordwell, and
K Williams
November 1971,
Ugeskrift for laeger,
H Zellweger, and
J Bardach, and
J Bordwell, and
K Williams
November 1970,
The Journal of pediatrics,
H Zellweger, and
J Bardach, and
J Bordwell, and
K Williams
March 1972,
La Nouvelle presse medicale,
H Zellweger, and
J Bardach, and
J Bordwell, and
K Williams
January 1980,
Revista de pediatrie, obstetrica si ginecologie. Pediatria,
H Zellweger, and
J Bardach, and
J Bordwell, and
K Williams
January 1979,
Acta paediatrica Belgica,
H Zellweger, and
J Bardach, and
J Bordwell, and
K Williams
June 1970,
Journal of medical genetics,
H Zellweger, and
J Bardach, and
J Bordwell, and
K Williams
June 1984,
Journal of medical genetics,
H Zellweger, and
J Bardach, and
J Bordwell, and
K Williams
July 1983,
Neuropsychiatrie de l'enfance et de l'adolescence,
H Zellweger, and
J Bardach, and
J Bordwell, and
K Williams
October 1967,
Maandschrift voor kindergeneeskunde,
